Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM8FD3Z)

Drug Name
HG-9-91-01 Drug Info
Synonyms HY-15776
Cross-matching ID
PubChem CID
78357808
ChEBI ID
CHEMBL4553284
TTD Drug ID
D03YVB

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.56 0.00e+0 93/133 (69.92%) ATP5MC3;COX7A2L;ATP5F1A;...
Glyoxylate and dicarboxylate metabolism 2.03 4.66e-3 23/30 (76.67%) GLUL;PCCB;CAT;...
Peroxisome 1.99 3.10e-3 72/82 (87.8%) SCP2;EPHX2;IDH2;...
Propanoate metabolism 1.98 2.33e-3 30/34 (88.24%) ABAT;PCCB;ALDH6A1;...
Diabetic cardiomyopathy 1.98 1.86e-3 162/203 (79.8%) AGT;ATP5MC3;PIK3R3;...
Non-alcoholic fatty liver disease 1.89 3.10e-3 126/155 (81.29%) CXCL8;CASP7;PIK3R3;...
Butanoate metabolism 1.85 9.31e-3 23/28 (82.14%) ABAT;ALDH5A1;BDH2;...
Citrate cycle (TCA cycle) 1.83 9.31e-3 30/30 (100%) IDH2;MDH1;OGDHL;...
Terpenoid backbone biosynthesis 1.79 1.76e-2 18/22 (81.82%) PCYOX1;ACAT2;HMGCS2;...
Valine, leucine and isoleucine degradation 1.76 2.05e-2 42/48 (87.5%) ABAT;PCCB;ALDH6A1;...
Parkinson disease 1.75 2.12e-2 176/249 (70.68%) ATP5MC3;COX7A2L;ATP5F1A;...
Primary bile acid biosynthesis 1.75 1.94e-2 15/17 (88.24%) SCP2;AMACR;ACOX2;...
Thermogenesis 1.75 1.79e-2 173/232 (74.57%) KDM3A;ATP5MC3;COX7A2L;...
Prion disease 1.73 1.93e-2 209/273 (76.56%) ATP5MC3;PIK3R3;COX7A2L;...
Legionellosis 1.70 2.61e-2 51/57 (89.47%) CD14;CXCL8;CASP7;...
Steroid biosynthesis 1.66 3.55e-2 19/20 (95%) DHCR7;MSMO1;SC5D;...
Tryptophan metabolism 1.65 4.00e-2 35/42 (83.33%) MAOA;CAT;IDO1;...
Huntington disease 1.65 4.09e-2 233/306 (76.14%) ATP5MC3;COX7A2L;ATP5F1A;...
Chronic myeloid leukemia -1.64 4.80e-2 72/76 (94.74%) IKBKG;CTBP2;HDAC2;...
Human papillomavirus infection -1.65 4.63e-2 284/331 (85.8%) TRAF3;CCNE1;HLA-C;...
Melanoma -1.66 4.02e-2 68/72 (94.44%) FGF1;FGF5;BAX;...
Hypertrophic cardiomyopathy -1.68 3.86e-2 81/90 (90%) TNNC1;ITGA5;ITGA10;...
Pathways in cancer -1.68 3.58e-2 474/531 (89.27%) MMP9;FGF1;CTBP2;...
Protein digestion and absorption -1.70 3.62e-2 78/103 (75.73%) COL11A1;CELA3B;COL10A1;...
Small cell lung cancer -1.72 3.18e-2 90/92 (97.83%) IKBKG;MAX;TRAF3;...
MicroRNAs in cancer -1.75 2.44e-2 146/310 (47.1%) MMP9;HDAC2;CCNE1;...
Thyroid cancer -1.76 2.35e-2 36/37 (97.3%) TPM3;BAX;TP53;...
Apelin signaling pathway -1.77 2.25e-2 117/137 (85.4%) TFAM;GNG10;LIPE;...
MAPK signaling pathway -1.78 2.12e-2 272/294 (92.52%) IKBKG;NTF3;IL1RAP;...
Adherens junction -1.79 2.29e-2 63/71 (88.73%) TCF7L1;BAIAP2;CTNND1;...
Ras signaling pathway -1.81 1.69e-2 201/232 (86.64%) IKBKG;PLA1A;NTF3;...
Proteoglycans in cancer -1.86 1.32e-2 172/205 (83.9%) ERBB4;FLNB;THBS1;...
PI3K-Akt signaling pathway -2.06 0.00e+0 317/354 (89.55%) FGF5;CCNE1;BCL2;...
Focal adhesion -2.13 0.00e+0 180/201 (89.55%) MAP2K1;FLNC;AKT3;...
ECM-receptor interaction -2.60 0.00e+0 80/88 (90.91%) LAMA5;COL9A2;LAMC1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUES 3 CVCL_B062 Homo sapiens 0.04uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H