Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM8HJX6)

• Drug Name: Tipranavir Drug Info
• Synonyms: Aptivus; TPV; PNU 140690; U 140690; Aptivus (Boehringer Ingelheim); Aptivus (TN); Aptivus(TM); PNU-140690; PNU-140690E; Tipranavir (INN); U-140690; N-[3-[(1R)-1-[(2R)-6-hydroxy-4-oxo-2-phenethyl-2-propyl-3H-pyran-5-yl]propyl]phenyl]-5-(trifluoromethyl)pyridine-2-sulfonamide; N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE
• Therapeutic Class: Anti-HIV Agents
• Cross-matching ID:
  PubChem CID: 54682461
  ChEBI ID: CHEMBL222559
  CAS Number: CAS 174484-41-4
  TTD Drug ID: D0EV6T
  VARIDT Drug ID: DR00962
  INTEDE Drug ID: DR1601

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Protein digestion and absorption	2.13	0.00e+0	78/103 (75.73%)	COL6A2;COL15A1;FXYD2;...
Primary immunodeficiency	2.10	0.00e+0	33/38 (86.84%)	ICOS;CD4;CD3D;...
Small cell lung cancer	1.81	3.76e-2	90/92 (97.83%)	E2F2;LAMA5;PIK3CB;...
ECM-receptor interaction	1.81	3.76e-2	80/88 (90.91%)	COL6A2;TNC;LAMA5;...
Carbohydrate digestion and absorption	1.78	4.52e-2	37/47 (78.72%)	FXYD2;MGAM;PIK3CB;...
Hematopoietic cell lineage	1.72	4.74e-2	90/99 (90.91%)	IL11RA;CD4;CD3D;...
Amoebiasis	1.72	4.77e-2	99/102 (97.06%)	GNAS;PRKCA;TLR2;...
Viral protein interaction with cytokine and cytokine re...	1.71	4.79e-2	84/100 (84%)	CXCL9;CXCL10;CXCL11;...
Oxidative phosphorylation	-1.76	4.55e-2	93/133 (69.92%)	ATP5MC1;COX17;NDUFS3;...
Epithelial cell signaling in Helicobacter pylori infect...	-1.88	1.14e-2	62/70 (88.57%)	PAK1;ATP6V0E1;JUN;...
PPAR signaling pathway	-1.94	2.28e-2	66/74 (89.19%)	SCD5;DBI;SLC27A6;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼