Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM8J24A)

Drug Name
IBC 293 Drug Info
Synonyms IBC293; IBC-293
Cross-matching ID
PubChem CID
2736690
ChEBI ID
CHEMBL381638
CAS Number
CAS 306935-41-1
TTD Drug ID
D0VE9G

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.02 5.26e-3 34/36 (94.44%) POLE2;MCM5;DNA2;...
Cell cycle 1.98 5.26e-3 110/124 (88.71%) PLK1;CDC20;ABL1;...
Autoimmune thyroid disease -1.82 4.13e-2 46/53 (86.79%) HLA-DPA1;CGA;HLA-DQA1;...
Allograft rejection -1.87 3.50e-2 32/38 (84.21%) HLA-DPA1;HLA-DQA1;HLA-A;...
Graft-versus-host disease -1.90 3.75e-2 32/42 (76.19%) HLA-DPA1;HLA-DQA1;HLA-A;...
Hematopoietic cell lineage -1.95 4.50e-2 90/99 (90.91%) GYPA;EPO;HLA-DPA1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H