Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM8KSQH)

• Drug Name: Phenoxybenzamine Drug Info
• Synonyms: Bensylyt; Bensylyte; Benzylyt; Dibenylene; Dibenylin; Dibenyline; Dibenziran; Dibenzylene; Dibenzylin; Dibenzyran; Fenossibenzamina; Fenoxibenzamina; Phenoxybenzaminum; Bensylyt NEN; Fenossibenzamina [DCIT]; POB HCl; Phenoxybenzamine Hcl; A 688; Dibenzyline (TN); Fenoxibenzamina [INN-Spanish]; Phenoxybenzamine (INN);Phenoxybenzamine [INN:BAN]; Phenoxybenzaminum [INN-Latin]; N-Phenoxyisopropyl-N-benzyl-beta-chloroethylamine; Benzyl(2-chloroethyl)-(1-methyl-2-phenoxyethyl)amine; N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine; N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine; N-benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-amine; N-(2-chloroethyl)-N-(phenylmethyl)-1-(phenyloxy)propan-2-amine; 2-(N-Benzyl-2-chloroethylamino)-1-phenoxypropane; 688A
• Therapeutic Class: Antihypertensive Agents
• Cross-matching ID:
  PubChem CID: 4768
  ChEBI ID: CHEMBL753
  CAS Number: CAS 59-96-1
  TTD Drug ID: D0X2DK
  VARIDT Drug ID: DR00696
  ACDINA Drug ID: D00526

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Ferroptosis	2.39	0.00e+0	36/41 (87.8%)	HMOX1;FTH1;STEAP3;...
Nitrogen metabolism	2.03	1.58e-2	16/17 (94.12%)	CA12;CA14;GLUD2;...
Mineral absorption	1.96	1.06e-2	48/60 (80%)	HMOX1;FTH1;MT1E;...
Glutathione metabolism	1.88	1.85e-2	43/57 (75.44%)	GSTO1;ANPEP;GPX4;...
Thiamine metabolism	1.85	2.11e-2	12/15 (80%)	AK5;ALPP;ACP1;...
Fructose and mannose metabolism	1.79	3.35e-2	30/33 (90.91%)	HK2;AKR1B1;PFKFB3;...
Purine metabolism	1.71	4.81e-2	102/129 (79.07%)	NME4;ADA2;PDE4B;...
Pyrimidine metabolism	1.71	4.44e-2	40/56 (71.43%)	NME4;TYMP;DPYD;...
Cysteine and methionine metabolism	1.69	4.51e-2	43/50 (86%)	BCAT1;BHMT;CBS;...
Retinol metabolism	-1.85	4.72e-2	41/68 (60.29%)	RPE65;DGAT1;CYP2C18;...
Steroid biosynthesis	-2.03	2.83e-2	19/20 (95%)	LBR;CYP24A1;DHCR24;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Hide ▲

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	10uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼