Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM8M1X0)

Drug Name
Ro-16-6028 Drug Info
Synonyms
Bretazenil; 84379-13-5; Ro 16-6028; UNII-OSZ0E9DGOJ; Bretazenil [USAN:INN]; 1-Bretazenil; Bretazenilum [INN-Latin]; Ro-16-6028; OSZ0E9DGOJ; BRN 4765855; C19H20BrN3O3; CHEMBL366947; NCGC00160640-01; DSSTox_RID_81493; DSSTox_CID_26266; DSSTox_GSID_46266; tert-Butyl (S)-8-bromo-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo(1,5-a)pyrrolo(2,1-c)(1,4)benzodiazepine-1-carboxylate; Bretazenilum; 9H-Imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid; 9H-Imidazo(1,5-a)pyrrolo(2,1-c)(1,4)benzodiazepine-1-carboxylic acid, 8-bro
Cross-matching ID
PubChem CID
107926
ChEBI ID
CHEMBL366947
CAS Number
CAS 84379-13-5
TTD Drug ID
D0B3LP

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Drug metabolism 1.68 1.77e-1 78/151 (51.66%) ADH5;MAOB;CES1;...
Phenylalanine metabolism 1.68 1.21e-1 14/17 (82.35%) PAH;MAOB;GLYAT;...
Non-homologous end-joining 1.66 1.10e-1 11/13 (84.62%) DCLRE1C;MRE11;XRCC5;...
Primary bile acid biosynthesis 1.62 1.33e-1 15/17 (88.24%) CH25H;AKR1D1;CYP39A1;...
Cholesterol metabolism 1.61 1.26e-1 44/50 (88%) APOC1;APOC2;APOA1;...
Spliceosome 1.60 1.16e-1 101/150 (67.33%) HSPA1A;LSM5;HSPA8;...
Complement and coagulation cascades 1.59 1.23e-1 76/85 (89.41%) PLAT;C7;CFI;...
Butanoate metabolism 1.59 1.10e-1 23/28 (82.14%) ACAT2;ABAT;ACSM5;...
Tyrosine metabolism 1.58 1.03e-1 30/36 (83.33%) ADH5;MAOB;HPD;...
Pyruvate metabolism 1.58 9.80e-2 41/47 (87.23%) ADH5;ACAT2;DLD;...
Glyoxylate and dicarboxylate metabolism 1.57 9.69e-2 23/30 (76.67%) ACAT2;DLD;GLDC;...
Valine, leucine and isoleucine degradation 1.54 1.12e-1 42/48 (87.5%) ACAT2;ABAT;DLD;...
Pentose and glucuronate interconversions 1.53 1.29e-1 17/34 (50%) SORD;UGT2B15;AKR1B10;...
Biosynthesis of unsaturated fatty acids 1.52 1.23e-1 21/27 (77.78%) HACD3;SCD5;ACOX1;...
Propanoate metabolism 1.52 1.16e-1 30/34 (88.24%) ACAT2;ABAT;DLD;...
Vitamin digestion and absorption 1.50 1.22e-1 17/24 (70.83%) APOA1;LMBRD1;MMACHC;...
Fatty acid degradation 1.50 1.18e-1 40/43 (93.02%) ADH5;ACAT2;ADH6;...
One carbon pool by folate 1.49 1.18e-1 15/20 (75%) MTR;DHFR;MTHFD1;...
DNA replication 1.49 1.20e-1 34/36 (94.44%) PCNA;RPA3;PRIM2;...
Thiamine metabolism 1.48 1.16e-1 12/15 (80%) AK4;ACP1;AK2
Oxidative phosphorylation 1.48 1.15e-1 93/133 (69.92%) COX7C;NDUFB1;COX4I1;...
beta-Alanine metabolism 1.46 1.22e-1 25/30 (83.33%) ABAT;ALDH6A1;EHHADH;...
Histidine metabolism 1.46 1.18e-1 16/22 (72.73%) MAOB;AOC1;ASPA;...
Arginine and proline metabolism 1.42 1.57e-1 39/50 (78%) MAOB;AOC1;PRODH2;...
Ascorbate and aldarate metabolism 1.41 1.73e-1 15/30 (50%) UGT2B15;ALDH7A1;RGN;...
Retinol metabolism 1.40 1.74e-1 41/68 (60.29%) ADH5;CYP1A2;ADH6;...
Homologous recombination 1.40 1.71e-1 35/41 (85.37%) TOPBP1;RAD54B;RPA3;...
Thyroid hormone synthesis 1.37 2.00e-1 66/75 (88%) GPX2;CGA;ALB;...
Glycine, serine and threonine metabolism 1.37 1.96e-1 31/40 (77.5%) MAOB;DLD;PIPOX;...
Alanine, aspartate and glutamate metabolism 1.36 2.06e-1 27/37 (72.97%) ABAT;ASPA;NIT2;...
Viral protein interaction with cytokine and cytokine re... -1.26 4.59e-1 84/100 (84%) CCL4;CCR10;CCL2;...
Various types of N-glycan biosynthesis -1.26 4.55e-1 26/39 (66.67%) MAN1B1;MAN2A2;MGAT2;...
Choline metabolism in cancer -1.27 4.41e-1 84/98 (85.71%) CHKA;TSC1;DGKD;...
JAK-STAT signaling pathway -1.27 4.50e-1 146/162 (90.12%) IL12A;IL11RA;PDGFRB;...
Renal cell carcinoma -1.28 4.48e-1 68/69 (98.55%) TGFA;EP300;CUL2;...
Influenza A -1.28 4.31e-1 156/172 (90.7%) IRF7;TLR3;CCL2;...
Transcriptional misregulation in cancer -1.29 4.28e-1 158/192 (82.29%) RXRG;PRCC;NTRK1;...
Amino sugar and nucleotide sugar metabolism -1.29 4.37e-1 38/48 (79.17%) CYB5R1;HK1;PMM1;...
Cell adhesion molecules -1.29 4.39e-1 118/148 (79.73%) PVR;ITGA8;CADM3;...
Central carbon metabolism in cancer -1.29 4.48e-1 67/70 (95.71%) HRAS;FGFR2;NTRK1;...
Insulin signaling pathway -1.29 4.59e-1 121/137 (88.32%) INPPL1;EXOC7;HRAS;...
Asthma -1.31 4.35e-1 25/31 (80.65%) IL3;HLA-DRB1;IL4;...
N-Glycan biosynthesis -1.32 4.39e-1 38/50 (76%) MAN1B1;MAN2A2;MGAT2;...
Sphingolipid metabolism -1.32 4.49e-1 32/49 (65.31%) SMPD2;SMPD3;ARSA;...
Insulin secretion -1.32 4.55e-1 75/86 (87.21%) INS;KCNN4;ATP1A3;...
ECM-receptor interaction -1.37 4.53e-1 80/88 (90.91%) ITGB3;ITGA2B;LAMC2;...
Hepatitis C -1.44 3.95e-1 139/157 (88.54%) RSAD2;PPP2R2D;PPP2CA;...
Thyroid hormone signaling pathway -1.48 3.22e-1 112/121 (92.56%) ATP1A3;BAD;CTNNB1;...
Glycosaminoglycan biosynthesis -1.50 2.94e-1 40/58 (68.97%) B3GNT2;CSGALNACT2;DSE;...
Focal adhesion -1.51 2.83e-1 180/201 (89.55%) FLT1;ITGA2B;PIK3CB;...
GnRH secretion -1.51 3.07e-1 60/64 (93.75%) PIK3CB;KCNN1;KCNJ3;...
Pancreatic secretion -1.51 3.35e-1 87/102 (85.29%) KCNMA1;ADCY6;PNLIPRP2;...
Circadian rhythm -1.52 3.60e-1 26/31 (83.87%) CREB1;RBX1;CRY2;...
Toll-like receptor signaling pathway -1.54 3.57e-1 94/104 (90.38%) CCL4;MYD88;FOS;...
Mitophagy -1.56 3.45e-1 56/68 (82.35%) SQSTM1;BCL2L13;MFN2;...
Bacterial invasion of epithelial cells -1.57 3.79e-1 59/77 (76.62%) PIK3CB;ELMO1;CDH1;...
Amoebiasis -1.59 3.59e-1 99/102 (97.06%) COL4A1;PRDX1;IL1R2;...
Galactose metabolism -1.60 4.20e-1 26/31 (83.87%) GCK;HK2;HK3;...
Viral myocarditis -1.73 1.81e-1 53/60 (88.33%) HLA-DRB1;SGCG;CASP9;...
Protein digestion and absorption -1.90 6.46e-2 78/103 (75.73%) MME;ELN;COL6A2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H