Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM8MNVO)

• Drug Name: Tolcapone Drug Info
• Synonyms: Tasmar; Roche brand of tolcapone; Ro 40-7592; Tasmar (TN); Tolcapone [USAN:INN]; Ro-40-7592; Tolcapone (JAN/USAN/INN); Methanone,(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl); (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone; (3,4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone; 3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone; 3,4-dihydroxy-5'-methyl-5-nitrobenzophenone
• Therapeutic Class: Antiparkinson Agents
• Cross-matching ID:
  PubChem CID: 4659569
  ChEBI ID: CHEMBL63630
  CAS Number: CAS 134308-13-7
  TTD Drug ID: D0Y7PG
  ACDINA Drug ID: D00686

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Type I diabetes mellitus	-1.73	3.52e-2	38/43 (88.37%)	INS;GAD1;IL1A;...
Neutrophil extracellular trap formation	-1.74	3.65e-2	101/189 (53.44%)	VDAC3;AZU1;NCF4;...
NF-kappa B signaling pathway	-1.78	2.39e-2	90/104 (86.54%)	TNFAIP3;DDX58;ICAM1;...
Glutathione metabolism	-1.79	2.55e-2	43/57 (75.44%)	OPLAH;GCLM;PGD;...
Graft-versus-host disease	-1.81	2.30e-2	32/42 (76.19%)	IL1A;CD86;HLA-DQB1;...
Histidine metabolism	-1.81	2.33e-2	16/22 (72.73%)	ASPA;MAOB;HDC;...
Leishmaniasis	-1.82	2.36e-2	67/77 (87.01%)	FCGR3B;NFKBIB;CR1;...
TNF signaling pathway	-1.85	2.42e-2	103/112 (91.96%)	IL18R1;TNFAIP3;MAPK13;...
Influenza A	-1.93	2.15e-2	156/172 (90.7%)	NFKBIB;IL1A;OAS1;...
Rheumatoid arthritis	-1.94	3.22e-2	78/93 (83.87%)	IL1A;CD86;MMP1;...
Hematopoietic cell lineage	-2.15	0.00e+0	90/99 (90.91%)	CSF3R;CD36;CSF1R;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	12uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼