Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM8P9ST)

Drug Name
PF-4800567 Drug Info
Synonyms PF4800567; PF 4800567
Cross-matching ID
PubChem CID
53472153
ChEBI ID
CHEMBL87237
CAS Number
CAS 1188296-52-7
TTD Drug ID
D06QYR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Fat digestion and absorption -1.67 3.21e-2 35/43 (81.4%) ABCG5;PLA2G5;DGAT1;...
Systemic lupus erythematosus -1.68 2.75e-2 45/135 (33.33%) HLA-DPB1;C9;ACTN4;...
ECM-receptor interaction -1.74 1.60e-2 80/88 (90.91%) ITGA7;ITGB3;ITGA9;...
Cholesterol metabolism -1.77 1.30e-2 44/50 (88%) ABCG5;LIPG;ANGPTL8;...
Pentose and glucuronate interconversions -1.78 1.25e-2 17/34 (50%) CRYL1;SORD;UGT2B4;...
Ovarian steroidogenesis -1.78 1.36e-2 41/51 (80.39%) HSD17B1;CYP2J2;HSD17B7;...
Vitamin digestion and absorption -1.79 1.39e-2 17/24 (70.83%) SLC19A1;SCARB1;APOB;...
Protein digestion and absorption -1.82 1.15e-2 78/103 (75.73%) COL11A1;COL11A2;SLC38A2;...
Mineral absorption -1.88 3.19e-3 48/60 (80%) HMOX1;HMOX2;MT2A;...
Steroid biosynthesis -1.93 0.00e+0 19/20 (95%) FDFT1;TM7SF2;SC5D;...
Steroid hormone biosynthesis -1.94 0.00e+0 43/61 (70.49%) SULT2B1;HSD3B1;CYP3A4;...
Retinol metabolism -1.95 0.00e+0 41/68 (60.29%) DHRS3;ADH1A;CYP2C9;...
Phagosome -1.96 0.00e+0 118/152 (77.63%) MARCO;ATP6V0A4;ITGB3;...
Metabolism of xenobiotics by cytochrome P450 -2.05 0.00e+0 49/77 (63.64%) ADH1A;EPHX1;CYP2C9;...
Staphylococcus aureus infection -2.12 0.00e+0 72/95 (75.79%) C3AR1;KRT36;CFH;...
PPAR signaling pathway -2.12 0.00e+0 66/74 (89.19%) FABP1;ME1;ACSL1;...
Complement and coagulation cascades -2.56 0.00e+0 76/85 (89.41%) SERPINF2;F13B;CFHR4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H