General Information of Drug (ID: DM8PTSY)

Drug Name
Prenylamine Drug Info
Synonyms
Prenilamina; Prenilamina [INN-Spanish]; Prenylamine (vasodilator); Prenylamine [USAN:INN:BAN]; Prenylaminum; Prenylaminum [INN-Latin]; Bismethin; Carditin; Corontin; Corpax; DL-Prenylamine; Difril; Elecor; Falliocor; Hostaginan; PRENYLAMINE; SAN 13-194; Sandoz 13-194; Segontin; Synadrin; Valecor; 1-Phenyl-2-(1',1'-diphenylpropyl-3'-amino)propane; 390-64-7; B-436; BRN 2060323; CHEMBL24072; EINECS 206-869-4; N-(1-Methyl-2-phenylethyl)-gamma-phenylbenzenepropanamine; N-(3,3-Diphenylpropyl)-alpha-methylphenethylamine
Cross-matching ID
PubChem CID
9801
ChEBI ID
CHEMBL24072
CAS Number
CAS 390-64-7
INTEDE Drug ID
DR1337

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Mineral absorption 1.72 4.15e-1 48/60 (80%) TF;MT1G;MT1M;...
Fanconi anemia pathway 1.65 3.79e-1 36/54 (66.67%) FANCL;REV3L;FANCA;...
Asthma 1.65 2.62e-1 25/31 (80.65%) HLA-DQA1;HLA-DOB;FCER1G;...
Taurine and hypotaurine metabolism 1.54 4.44e-1 8/11 (72.73%) GAD1;ADO;CSAD
Mucin type O-glycan biosynthesis 1.53 3.93e-1 20/36 (55.56%) GALNT7;GCNT3;GALNT12;...
Type I diabetes mellitus 1.53 3.53e-1 38/43 (88.37%) HLA-DQA1;GAD1;PTPRN2;...
Mismatch repair 1.53 3.04e-1 22/23 (95.65%) PCNA;RFC5;RPA2;...
Glycosaminoglycan biosynthesis 1.48 3.77e-1 40/58 (68.97%) HS3ST1;CHST1;B4GALT4;...
D-Glutamine and D-glutamate metabolism 1.44 4.53e-1 5/5 (100%) DGLUCY;GLS;GLS2
GABAergic synapse 1.41 5.16e-1 76/89 (85.39%) SLC38A1;GABRP;GAD1;...
Glutamatergic synapse 1.41 4.71e-1 97/114 (85.09%) SLC38A1;SLC1A1;GNG7;...
Epithelial cell signaling in Helicobacter pylori infect... 1.41 4.32e-1 62/70 (88.57%) CXCL8;PAK1;PLCG2;...
Caffeine metabolism 1.41 4.11e-1 5/6 (83.33%) NAT2;XDH;CYP1A2
Transcriptional misregulation in cancer 1.40 4.21e-1 158/192 (82.29%) PROM1;CXCL8;TMPRSS2;...
Retinol metabolism 1.40 4.02e-1 41/68 (60.29%) DHRS9;ALDH1A1;ALDH1A3;...
Pyrimidine metabolism 1.39 3.92e-1 40/56 (71.43%) NT5E;RRM2;ENTPD1;...
Salivary secretion 1.38 3.94e-1 76/93 (81.72%) LYZ;CST3;KCNN4;...
Antigen processing and presentation 1.37 4.06e-1 60/78 (76.92%) CALR;HLA-DQA1;LGMN;...
Cell cycle 1.36 4.12e-1 110/124 (88.71%) SMC1A;WEE1;CDKN1A;...
Phosphatidylinositol signaling system 1.35 4.18e-1 82/97 (84.54%) CDS1;INPP4B;DGKA;...
Allograft rejection 1.34 4.35e-1 32/38 (84.21%) HLA-DQA1;HLA-DOB;CD40;...
Intestinal immune network for IgA production 1.34 4.18e-1 38/48 (79.17%) HLA-DQA1;HLA-DOB;CD40;...
IL-17 signaling pathway 1.31 4.80e-1 84/94 (89.36%) S100A8;S100A9;CXCL8;...
Ferroptosis 1.31 4.67e-1 36/41 (87.8%) TF;SLC39A8;ACSL5;...
Vitamin digestion and absorption 1.29 5.06e-1 17/24 (70.83%) SLC5A6;ABCC1;APOA4;...
Shigellosis 1.25 5.76e-1 180/246 (73.17%) TNIP1;CXCL8;CAPN2;...
Type II diabetes mellitus 1.25 5.63e-1 42/46 (91.3%) HK2;INSR;SOCS1;...
NF-kappa B signaling pathway 1.25 5.72e-1 90/104 (86.54%) CXCL8;PTGS2;PLCG2;...
Phosphonate and phosphinate metabolism 1.24 5.62e-1 5/6 (83.33%) CEPT1;PCYT2;CHPT1
Viral myocarditis 1.23 5.77e-1 53/60 (88.33%) BID;HLA-DQA1;CD55;...
Huntington disease -1.42 1.51e-1 233/306 (76.14%) PLCB1;ACTR1A;NDUFA7;...
Pentose and glucuronate interconversions -1.42 1.50e-1 17/34 (50%) XYLB;KL;UGP2;...
Aldosterone-regulated sodium reabsorption -1.48 1.42e-1 34/37 (91.89%) ATP1B4;SCNN1A;ATP1B3;...
Folate biosynthesis -1.48 1.44e-1 23/26 (88.46%) AKR1B10;AKR1B1;GCH1;...
Prion disease -1.49 1.34e-1 209/273 (76.56%) NDUFA10;COX5B;PSMA3;...
Pyruvate metabolism -1.50 1.28e-1 41/47 (87.23%) PC;GLO1;LDHA;...
Dilated cardiomyopathy -1.51 1.23e-1 86/96 (89.58%) SGCG;CACNA2D2;AGT;...
Relaxin signaling pathway -1.52 1.19e-1 114/129 (88.37%) MAP2K4;ATF6B;GNG5;...
PPAR signaling pathway -1.53 1.08e-1 66/74 (89.19%) ACADM;PLIN1;RXRA;...
Aminoacyl-tRNA biosynthesis -1.54 1.12e-1 15/66 (22.73%) SARS2;TARS2;GATB;...
AMPK signaling pathway -1.55 1.09e-1 106/120 (88.33%) PIK3R3;ACACB;RAB8A;...
Hypertrophic cardiomyopathy -1.56 9.87e-2 81/90 (90%) PRKAB2;ITGA1;MYL3;...
Oxidative phosphorylation -1.57 9.81e-2 93/133 (69.92%) PPA2;ATP6V1B1;NDUFA7;...
Propanoate metabolism -1.57 1.02e-1 30/34 (88.24%) LDHA;BCKDHA;ECHS1;...
AGE-RAGE signaling pathway in diabetic complications -1.61 7.52e-2 97/100 (97%) NOX4;STAT1;NOX1;...
Malaria -1.61 7.50e-2 44/50 (88%) GYPA;HGF;SELE;...
Tryptophan metabolism -1.62 7.41e-2 35/42 (83.33%) ALDH3A2;DDC;DLST;...
Fatty acid elongation -1.62 7.89e-2 19/27 (70.37%) ELOVL5;ACOT7;ACAA2;...
Biosynthesis of unsaturated fatty acids -1.63 8.37e-2 21/27 (77.78%) FADS1;ELOVL4;SCD5;...
Terpenoid backbone biosynthesis -1.63 8.62e-2 18/22 (81.82%) PCYOX1;FNTB;FDPS;...
Melanoma -1.66 7.61e-2 68/72 (94.44%) MET;FGF1;RAF1;...
Glyoxylate and dicarboxylate metabolism -1.66 8.09e-2 23/30 (76.67%) HAO2;AGXT;CAT;...
Cysteine and methionine metabolism -1.67 8.83e-2 43/50 (86%) TST;ADI1;CDO1;...
Complement and coagulation cascades -1.68 8.35e-2 76/85 (89.41%) CFHR2;C1QA;F2R;...
Cardiac muscle contraction -1.69 8.83e-2 64/87 (73.56%) TRDN;MYL3;MYL4;...
Citrate cycle (TCA cycle) -1.69 1.06e-1 30/30 (100%) DLST;ACO2;IDH1;...
Arginine and proline metabolism -1.70 1.19e-1 39/50 (78%) GAMT;NOS2;PRODH;...
TGF-beta signaling pathway -1.78 7.72e-2 81/94 (86.17%) SMAD5;BMP5;E2F5;...
Valine, leucine and isoleucine degradation -1.79 7.17e-2 42/48 (87.5%) PCCA;HMGCS2;ACAA2;...
Diabetic cardiomyopathy -1.80 1.43e-1 162/203 (79.8%) SP1;NDUFA9;NDUFS4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H