Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM8QM5U)

Drug Name
Anidulafungin Drug Info
Synonyms Ecalta; Eraxis; Anidulafungin [USAN:INN]; Ecalta (TN); Eraxis (TN); LY-303366; V-Echinocandin; VER-002
Therapeutic ClassAntifungal Agents
Cross-matching ID
PubChem CID
166548
ChEBI ID
CHEMBL264241
CAS Number
CAS 166663-25-8
TTD Drug ID
D0F9BY

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycerophospholipid metabolism -1.70 4.36e-2 71/98 (72.45%) PCYT1A;PLA2G10;PNPLA6;...
Toxoplasmosis -1.74 3.10e-2 103/112 (91.96%) TNF;NOS2;LAMC1;...
Hematopoietic cell lineage -1.79 2.04e-2 90/99 (90.91%) EPOR;TNF;FCER2;...
alpha-Linolenic acid metabolism -1.87 3.77e-3 17/25 (68%) PLA2G10;PLA2G1B;PLA2G4C;...
ECM-receptor interaction -1.87 4.71e-3 80/88 (90.91%) LAMC1;LAMA5;LAMB1;...
Ether lipid metabolism -1.94 0.00e+0 32/49 (65.31%) GDPD3;PLA2G12A;GAL3ST1;...
Retinol metabolism -1.94 0.00e+0 41/68 (60.29%) CYP2C18;CYP3A4;CYP3A7;...
Linoleic acid metabolism -1.98 0.00e+0 21/29 (72.41%) CYP2J2;CYP2C8;PLA2G12A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H