Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM8SXYG)

Drug Name
Lamotrigine Drug Info
Synonyms
Crisomet; Labileno; Lamictal; Lamictin; Lamiktal; Lamitor; Lamotrigina; Lamotriginum; Desitin Brand of Lamotrigine; Faes Brand of Lamotrigine; Glaxo Wellcome Brand of Lamotrigine; GlaxoSmithKline Brand of Lamotrigine; Juste Brand of Lamotrigine; Lamictal Cd; Lamictal ODT; Lamictal XR; Lamotrigina [Spanish]; Lamotriginum [Latin]; BW 430C; GI 267119X; GW 273293; L 3791; BW-430C; EUR-1048; Lamictal (TN); Lamictin (TN); Lamotrigine [USAN:INN:BAN]; Lamotrigine (JAN/USAN/INN); 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine; 3,5-Diamino-6-(2,3-dichlorophenyl)-as-triazine; 3,5-diamino-6-(2,3-dichlorophenyl)-as-triazine; 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine; 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diyldiamine; 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
Therapeutic ClassAnticonvulsants
Cross-matching ID
PubChem CID
3878
ChEBI ID
CHEMBL6367
CAS Number
CAS 84057-84-1
TTD Drug ID
D03FLC
VARIDT Drug ID
DR00056
INTEDE Drug ID
DR0913
ACDINA Drug ID
D00348

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.21 0.00e+0 34/36 (94.44%) POLE2;MCM5;MCM2;...
Proteasome 2.13 0.00e+0 44/46 (95.65%) PSMB4;POMP;PSMA7;...
Ribosome 2.01 2.58e-3 113/158 (71.52%) MRPL15;RPS4Y1;MRPS16;...
Cell cycle 1.98 3.87e-3 110/124 (88.71%) CDC20;CCNB2;CCNA2;...
Oxidative phosphorylation 1.94 1.08e-2 93/133 (69.92%) ATP5F1C;NDUFAB1;NDUFB6;...
Mismatch repair 1.83 2.07e-2 22/23 (95.65%) RPA3;RFC2;POLD2;...
Parkinson disease 1.83 1.77e-2 176/249 (70.68%) ATP5F1C;NDUFAB1;NDUFB6;...
RNA polymerase 1.81 1.55e-2 23/31 (74.19%) POLR2D;POLR2G;POLR1D;...
Purine metabolism 1.79 1.98e-2 102/129 (79.07%) AK4;NT5E;HPRT1;...
Thiamine metabolism 1.77 2.48e-2 12/15 (80%) AK4;ALPL;AK5;...
IL-17 signaling pathway 1.73 2.96e-2 84/94 (89.36%) S100A8;S100A9;S100A7;...
Proximal tubule bicarbonate reclamation 1.71 3.74e-2 21/23 (91.3%) CA2;SLC4A4;PCK1;...
Pyrimidine metabolism 1.70 3.81e-2 40/56 (71.43%) TYMS;NT5E;DUT;...
Huntington disease 1.69 3.82e-2 233/306 (76.14%) GRIA2;ATP5F1C;NDUFAB1;...
Cytosolic DNA-sensing pathway 1.68 4.29e-2 52/63 (82.54%) CXCL10;CCL4;IL33;...
Glycerolipid metabolism -1.75 4.96e-2 44/61 (72.13%) DGKG;ALDH9A1;AGPAT2;...
Cholesterol metabolism -1.77 4.07e-2 44/50 (88%) ABCG5;TSPO;ANGPTL8;...
Autophagy -1.87 1.80e-2 113/169 (66.86%) AKT1;HIF1A;NRBF2;...
Lysosome -1.92 1.29e-2 115/128 (89.84%) ABCB9;PSAP;LAMP2;...
Ferroptosis -1.95 4.29e-3 36/41 (87.8%) SLC3A2;GCLM;GPX4;...
Regulation of lipolysis in adipocytes -2.06 0.00e+0 52/55 (94.55%) PLIN1;TSHR;IRS2;...
Steroid biosynthesis -2.15 0.00e+0 19/20 (95%) MSMO1;LIPA;FDFT1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 12.5uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H