Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM8TNX3)

Drug Name
Etizolam Drug Info
Synonyms
Etizolam [INN:JAN]; Etizolamum [INN-Latin]; VMZUTJCNQWMAGF-UHFFFAOYSA-N; Y 7131; Y-7131; etizolam; 4-(2-chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine; 40054-69-1; 6-(o-Chlorophenyl)-8-ethyl-1-methyl-4H-s-triazolo(3,4-c)thieno(2,3-e)(1,4)-diazepine; 8-Ethyl-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo(3,4c)thieno(2,3e)-1,4-diazepine; A76XI0HL37; AHR 3219; BRN 0572740; C17H15ClN4S; Depas; NCGC00182031-01; UNII-A76XI0HL37
Cross-matching ID
PubChem CID
3307
ChEBI ID
CHEMBL31583
CAS Number
CAS 40054-69-1
INTEDE Drug ID
DR0665

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.39 0.00e+0 34/36 (94.44%) POLE2;PRIM1;RPA2;...
Oxidative phosphorylation 2.36 0.00e+0 93/133 (69.92%) COX7A1;ATP6V1D;NDUFB6;...
Mismatch repair 2.15 0.00e+0 22/23 (95.65%) MSH2;EXO1;RPA2;...
Parkinson disease 2.00 0.00e+0 176/249 (70.68%) DAXX;GNAS;COX7A1;...
Cell cycle 2.00 0.00e+0 110/124 (88.71%) CDC45;CDKN2A;CDKN2C;...
Spliceosome 1.94 0.00e+0 101/150 (67.33%) HSPA1A;PUF60;SRSF7;...
Amyotrophic lateral sclerosis 1.90 2.66e-3 267/364 (73.35%) DAXX;COX7A1;TUBB2A;...
Huntington disease 1.88 2.33e-3 233/306 (76.14%) PPARG;COX7A1;TUBB2A;...
Thermogenesis 1.88 2.07e-3 173/232 (74.57%) PPARG;GNAS;ACSL5;...
Homologous recombination 1.85 1.86e-3 35/41 (85.37%) BRCA1;BARD1;RPA2;...
Biosynthesis of unsaturated fatty acids 1.80 8.47e-3 21/27 (77.78%) SCD5;ELOVL2;BAAT;...
RNA transport 1.79 1.01e-2 128/186 (68.82%) EIF4EBP2;EIF2S1;RPP30;...
Diabetic cardiomyopathy 1.74 1.72e-2 162/203 (79.8%) COX7A1;SLC25A5;NDUFB6;...
Fanconi anemia pathway 1.73 2.20e-2 36/54 (66.67%) HES1;BRCA1;FANCI;...
Oocyte meiosis 1.72 2.24e-2 90/129 (69.77%) STAG3;PPP3CB;PTTG1;...
Citrate cycle (TCA cycle) 1.72 2.10e-2 30/30 (100%) IDH2;DLAT;PDHB;...
Prion disease 1.71 2.63e-2 209/273 (76.56%) COX7A1;TUBB2A;CYCS;...
Nucleotide excision repair 1.69 2.74e-2 40/47 (85.11%) POLE2;RPA2;LIG1;...
Propanoate metabolism 1.69 2.89e-2 30/34 (88.24%) PCCB;ACAT2;MLYCD;...
Base excision repair 1.68 2.75e-2 29/33 (87.88%) TDG;POLE2;NEIL3;...
Pyruvate metabolism 1.63 4.39e-2 41/47 (87.23%) ADH5;GLO1;ACYP2;...
ECM-receptor interaction -1.71 4.34e-2 80/88 (90.91%) SDC1;SDC4;DMP1;...
Necroptosis -1.78 2.42e-2 113/159 (71.07%) TNFAIP3;SQSTM1;PYCARD;...
Apoptosis -1.78 2.66e-2 126/168 (75%) ATF4;PIK3CA;PIDD1;...
Pertussis -1.81 1.54e-2 64/76 (84.21%) IRF3;GNAI2;ITGB1;...
Cytosolic DNA-sensing pathway -1.82 1.33e-2 52/63 (82.54%) MAVS;POLR2F;POLR2L;...
Lysosome -1.88 7.60e-3 115/128 (89.84%) HGSNAT;PPT2;LAPTM5;...
Cytokine-cytokine receptor interaction -1.89 8.87e-3 246/295 (83.39%) LIF;BMP8B;CCR9;...
Primary immunodeficiency -1.89 1.06e-2 33/38 (86.84%) IL2RG;CD4;TAP1;...
Viral protein interaction with cytokine and cytokine re... -1.91 1.33e-2 84/100 (84%) CCR9;CX3CL1;CSF1R;...
Chagas disease -1.94 1.77e-2 93/102 (91.18%) GNAQ;TGFB3;GNAI2;...
TNF signaling pathway -2.00 0.00e+0 103/112 (91.96%) ATF4;LIF;PIK3CA;...
Hematopoietic cell lineage -2.07 0.00e+0 90/99 (90.91%) HLA-DPA1;CD4;GYPA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H