Details of the Drug Pharmacogenomic Perturbation Atlas

Methantheline Drug Info

Mantheline; Methanide; Methanthelinium; Methanthelinum; Banthine bromide; Gastrin I; Methanthine bromide; Gastrin-1 Human; Diethyl-methyl-[2-(9H-xanthene-9-carbonyloxy)ethyl]azanium; N,N-Diethyl-N-methyl-2-[(9H-xanthen-9-ylcarbonyl)oxy]ethanaminium

Therapeutic Class

Anticholinergic Agents

Cross-matching ID

PubChem CID

4097

ChEBI ID

CHEMBL6817

CAS Number

CAS 5818-17-7

TTD Drug ID

D0JY5S

General Information of Drug (ID: DM8X4A1)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	1.91	4.28e-2	34/36 (94.44%)	MCM5;RPA1;MCM2;...
Prion disease	1.89	2.14e-2	209/273 (76.56%)	CYBA;C7;BAD;...
Parkinson disease	1.88	1.43e-2	176/249 (70.68%)	MAOB;PSMA6;GNAS;...
Histidine metabolism	1.84	2.14e-2	16/22 (72.73%)	MAOB;HNMT;CNDP2;...
Proteasome	1.84	1.71e-2	44/46 (95.65%)	PSMA6;PSMD11;PSMB7;...
Tyrosine metabolism	1.83	1.43e-2	30/36 (83.33%)	MAOB;ALDH3A1;ADH1C;...
Drug metabolism	1.77	2.75e-2	78/151 (51.66%)	MAOB;ALDH3A1;ADH1C;...
Metabolism of xenobiotics by cytochrome P450	1.74	4.01e-2	49/77 (63.64%)	CBR3;ALDH3A1;ADH1C;...
Homologous recombination	1.70	4.52e-2	35/41 (85.37%)	NBN;RAD54B;RPA1;...
TGF-beta signaling pathway	-1.95	1.91e-2	81/94 (86.17%)	SMAD4;FST;TGFBR1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H

Prostate

Prostate carcinoma

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H