Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM92P0F)

• Drug Name: Sisomicin Drug Info
• Synonyms: Siseptin; Sisomicin sulfate; Sisomicina [INN-Spanish]; Sisomicine; Sisomicine [INN-French]; Sisomicinum; Sisomicinum [INN-Latin]; Sisomin; Sisomycin; Sissomicin; X55XSL74YQ; sisomicin; 32385-11-8; BRN 1357913; C19H37N5O7; Antibiotic 66-40; Antibiotic 6640; Dehydrogentamicin Cla; Rickamicin; Sch 13475; Sch-13475; CHEBI:9169; D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-glycero-hex-4-enopyranosyl-(1-4))-2-deoxy-; EINECS 251-018-2; UNII-X55XSL74YQ
• Cross-matching ID:
  PubChem CID: 36119
  ChEBI ID: CHEMBL9169
  CAS Number: CAS 32385-11-8
  INTEDE Drug ID: DR2408

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Viral protein interaction with cytokine and cytokine re...	1.96	0.00e+0	84/100 (84%)	CXCL12;CCL20;CXCL1;...
Adherens junction	-1.84	3.33e-2	63/71 (88.73%)	EP300;IQGAP1;TGFBR2;...
Porphyrin and chlorophyll metabolism	-1.99	6.34e-3	23/43 (53.49%)	HMOX2;UGT2A3;HMBS;...
Bile secretion	-2.02	9.52e-3	68/90 (75.56%)	ATP1B4;SLC4A4;BAAT;...
Steroid hormone biosynthesis	-2.07	9.52e-3	43/61 (70.49%)	HSD17B2;AKR1D1;CYP11B1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲