Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM93VBZ)

Drug Name
LY2835219 Drug Info
Synonyms Abemaciclib; 1231929-97-7; Verzenio; LY-2835219; UNII-60UAB198HK; LY2835219 (free base);
Cross-matching ID
PubChem CID
46220502
ChEBI ID
CHEMBL3301610
CAS Number
CAS 1231929-97-7
TTD Drug ID
D05SBO
VARIDT Drug ID
DR00097
INTEDE Drug ID
DR0028
ACDINA Drug ID
D00003

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Citrate cycle (TCA cycle) 2.22 0.00e+0 30/30 (100%) MDH2;IDH3B;ACO2;...
Valine, leucine and isoleucine degradation 2.00 0.00e+0 42/48 (87.5%) ACAA1;ACAT1;HADHA;...
beta-Alanine metabolism 1.92 7.07e-3 25/30 (83.33%) HADHA;ABAT;CNDP2;...
Lysosome 1.89 7.96e-3 115/128 (89.84%) ASAH1;LAPTM4B;IGF2R;...
Glycolysis / Gluconeogenesis 1.81 1.91e-2 56/67 (83.58%) ALDH2;GPI;PFKL;...
Fatty acid degradation 1.80 1.77e-2 40/43 (93.02%) ACAA1;ACAT1;HADHA;...
Pentose phosphate pathway 1.76 1.82e-2 25/30 (83.33%) TKT;GPI;PFKL;...
Aminoacyl-tRNA biosynthesis 1.75 1.86e-2 15/66 (22.73%) LARS2;CARS2;QRSL1;...
Tryptophan metabolism 1.73 2.59e-2 35/42 (83.33%) ACAT1;HADHA;ALDH8A1;...
Synaptic vesicle cycle 1.72 2.55e-2 63/78 (80.77%) ATP6V0E2;ATP6V1F;ATP6V0E1;...
DNA replication -1.90 2.38e-2 34/36 (94.44%) POLE;MCM6;PRIM2;...
Cell cycle -2.00 0.00e+0 110/124 (88.71%) CDC27;CDKN2A;MDM2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 BRD4 (-) 1 CVCL_SF59 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Breast
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.66uM - 3.33uM 24H