Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM96FA1)

• Drug Name: Drotaverine Drug Info
• Synonyms: drotaverine; Drotaverin; 14009-24-6; dihydroisoperparine; Drotaverine [INN]; No-Spa; Drotaverinum [INN-Latin]; Drotaverina [INN-Spanish]; UNII-98QS4N58TW; 98QS4N58TW; C24H31NO4; Drotaverine (INN); Drotin; isodihydroperparine; 1-(3,4-Diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline; (1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,4-dihydro-2H-isoquinoline; Drotaverina; Drotaverinum; Nospanum; 1-Benzyl-3',4',6,7-tetraethoxy-1,2,3,4-tetrahydroisoquinoline; No-shpa; 985-12-6; Drotin (TN); DIHYDROETHAVERINE
• Cross-matching ID:
  PubChem CID: 1712095
  ChEBI ID: CHEMBL551978
  CAS Number: CAS 14009-24-6
  TTD Drug ID: D06XAE

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Propanoate metabolism	2.13	0.00e+0	30/34 (88.24%)	DLD;ACACA;ABAT;...
Biosynthesis of unsaturated fatty acids	2.07	0.00e+0	21/27 (77.78%)	ELOVL2;ELOVL5;ELOVL4;...
Phenylalanine metabolism	2.00	0.00e+0	14/17 (82.35%)	MAOB;MAOA;PAH;...
Tryptophan metabolism	1.99	0.00e+0	35/42 (83.33%)	DLD;MAOB;MAOA;...
Glyoxylate and dicarboxylate metabolism	1.95	0.00e+0	23/30 (76.67%)	DLD;AMT;SHMT2;...
Valine, leucine and isoleucine degradation	1.94	0.00e+0	42/48 (87.5%)	DLD;ACAD8;ABAT;...
Histidine metabolism	1.85	6.87e-3	16/22 (72.73%)	MAOB;MAOA;ALDH2;...
Cysteine and methionine metabolism	1.84	6.01e-3	43/50 (86%)	AMD1;CDO1;PHGDH;...
Pantothenate and CoA biosynthesis	1.80	6.53e-3	14/21 (66.67%)	DPYD;ALDH2;BCAT1;...
beta-Alanine metabolism	1.78	1.07e-2	25/30 (83.33%)	DPYD;ABAT;ALDH2;...
Glycine, serine and threonine metabolism	1.72	1.94e-2	31/40 (77.5%)	DLD;AMT;MAOB;...
Oxidative phosphorylation	1.72	1.78e-2	93/133 (69.92%)	NDUFS8;NDUFS4;ATP5PD;...
Citrate cycle (TCA cycle)	1.63	3.74e-2	30/30 (100%)	DLD;IDH1;CS;...
Kaposi sarcoma-associated herpesvirus infection	-1.73	4.50e-2	172/193 (89.12%)	AKT3;IL6ST;GNB1;...
HIF-1 signaling pathway	-1.76	3.46e-2	105/109 (96.33%)	AKT3;IFNGR2;RPS6KB2;...
Malaria	-1.77	3.37e-2	44/50 (88%)	TLR4;THBS4;SELE;...
Transcriptional misregulation in cancer	-1.78	3.14e-2	158/192 (82.29%)	PRCC;MPO;CD86;...
Lipid and atherosclerosis	-1.80	2.55e-2	190/215 (88.37%)	TICAM1;MAP2K3;NFE2L2;...
Rheumatoid arthritis	-1.81	2.50e-2	78/93 (83.87%)	TLR4;JUN;ATP6V0B;...
Viral protein interaction with cytokine and cytokine re...	-1.83	2.44e-2	84/100 (84%)	IL2RA;CCL21;ACKR3;...
Legionellosis	-1.84	2.79e-2	51/57 (89.47%)	NFKBIA;MYD88;IL18;...
Small cell lung cancer	-1.90	1.50e-2	90/92 (97.83%)	GADD45A;TRAF2;LAMC3;...
Cytokine-cytokine receptor interaction	-1.95	9.00e-3	246/295 (83.39%)	BMP10;CLCF1;TNFRSF11A;...
Bladder cancer	-1.96	1.12e-2	40/41 (97.56%)	MYC;MAP2K2;MMP2;...
IL-17 signaling pathway	-1.99	1.50e-2	84/94 (89.36%)	CSF2;FADD;CCL2;...
NF-kappa B signaling pathway	-2.04	7.50e-3	90/104 (86.54%)	IKBKG;NFKBIA;MYD88;...
TNF signaling pathway	-2.37	0.00e+0	103/112 (91.96%)	SELE;IL15;MAP3K8;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲