Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM96VWD)

Drug Name
PINOCEMBRIN Drug Info
Synonyms
Pinocembrin; 480-39-7; (+)-Pinocembrin; (2S)-pinocembrin; Dihydrochrysin; UNII-8T7C8CH791; NSC 43318; NSC 279005; NSC 661207; 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (2S)-; (S)-5,7-dihydroxyflavanone; (S)-5,7-dihydroxy-2-phenylchroman-4-one; CHEMBL399910; CHEBI:28157; (2s)-5,7-dihydroxy-2-phenyl-2,3-dihydro-4h-chromen-4-one; (S)-2,3-Dihydro-5,7-dihydroxy-2-phenyl-4H-1-benzopyran-4-one; 8T7C8CH791; Pinocembrin (6CI); 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (-)-
Cross-matching ID
PubChem CID
68071
ChEBI ID
CHEMBL28157
CAS Number
CAS 480-39-7
TTD Drug ID
D0G5CS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.31 0.00e+0 34/36 (94.44%) MCM5;POLE;MCM2;...
Mismatch repair 1.92 2.34e-2 22/23 (95.65%) PCNA;RFC2;RPA1;...
Focal adhesion 1.85 3.12e-2 180/201 (89.55%) LAMA4;LAMB1;SRC;...
Cell cycle 1.84 2.57e-2 110/124 (88.71%) CDC20;CDC45;SMC1A;...
Collecting duct acid secretion -1.64 4.68e-2 22/27 (81.48%) ATP4B;TCIRG1;CLCNKB;...
Cholesterol metabolism -1.65 4.95e-2 44/50 (88%) PLTP;APOH;ABCG5;...
Viral protein interaction with cytokine and cytokine re... -1.69 3.27e-2 84/100 (84%) CCR6;CXCL11;IL6R;...
TNF signaling pathway -1.71 2.58e-2 103/112 (91.96%) ATF6B;CEBPB;CSF2;...
Cytokine-cytokine receptor interaction -1.73 1.86e-2 246/295 (83.39%) CCL11;TNFRSF12A;IL1R2;...
Mineral absorption -1.73 2.06e-2 48/60 (80%) TRPV6;FXYD2;ATP7A;...
Ferroptosis -1.74 2.18e-2 36/41 (87.8%) ALOX15;ACSL3;GCLC;...
Ascorbate and aldarate metabolism -1.75 2.50e-2 15/30 (50%) UGT2A3;UGT2B15;UGT2B17;...
Pentose and glucuronate interconversions -1.83 1.64e-2 17/34 (50%) UGT2A3;UGT2B15;UGT2B17;...
Metabolism of xenobiotics by cytochrome P450 -1.86 1.53e-2 49/77 (63.64%) SULT2A1;CYP2E1;CYP3A4;...
Porphyrin and chlorophyll metabolism -1.91 1.09e-2 23/43 (53.49%) UGT2A3;UGT2B15;UGT2B17;...
Steroid biosynthesis -1.97 7.28e-3 19/20 (95%) NSDHL;CYP51A1;SC5D;...
Staphylococcus aureus infection -1.99 5.46e-3 72/95 (75.79%) C1S;DEFB4A;HLA-DOB;...
Complement and coagulation cascades -2.06 0.00e+0 76/85 (89.41%) F2;C6;C8G;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H