Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM9BI3Y)

Drug Name
R7128 Drug Info
Synonyms R-4048; R-7128; RG-7128; RO-5024048
Cross-matching ID
PubChem CID
16122663
CAS Number
CAS 940908-79-2
TTD Drug ID
D06QOF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Staphylococcus aureus infection 1.95 2.26e-2 72/95 (75.79%) DEFB1;C3;CFB;...
IL-17 signaling pathway 1.93 1.69e-2 84/94 (89.36%) S100A9;CXCL8;NFKB1;...
Systemic lupus erythematosus 1.81 4.51e-2 45/135 (33.33%) C3;C1QB;IFNG;...
Viral protein interaction with cytokine and cytokine re... 1.79 4.79e-2 84/100 (84%) CCL5;CCL4;TNFSF10;...
Complement and coagulation cascades 1.78 4.51e-2 76/85 (89.41%) C3;CLU;CFB;...
Phosphatidylinositol signaling system -1.80 2.29e-2 82/97 (84.54%) MTMR3;ITPR2;PIP5K1B;...
Ascorbate and aldarate metabolism -1.83 1.71e-2 15/30 (50%) UGT2B15;UGT2A3;GUSB;...
Biosynthesis of unsaturated fatty acids -1.86 1.29e-2 21/27 (77.78%) ELOVL1;TECR;ACOT7;...
Pyruvate metabolism -1.91 5.72e-3 41/47 (87.23%) ME2;ACAT1;LDHA;...
Glycerolipid metabolism -1.92 4.29e-3 44/61 (72.13%) MGLL;PNPLA2;LPIN2;...
Inositol phosphate metabolism -2.03 0.00e+0 66/73 (90.41%) PIK3CD;MINPP1;PLCB3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H