Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM9BI7M)

• Drug Name: Duloxetine Drug Info
• Synonyms: Yentreve; LY 248686; Cymbalta (TN); Duloxetine (INN); Duloxetine [INN:BAN]; Yentreve (TN); Duloxetine, (+)-isomer; (3S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine; (3S)-N-methyl-3-(naphthalen-1-yloxy)-3-(2-thienyl)propan-1-amine; (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine; (S)-Duloxetine; (S)-N-Methyl-gamma-(1-naphthalenyloxy)-2-thiophenepropanamine
• Therapeutic Class: Antidepressants
• Cross-matching ID:
  PubChem CID: 60835
  ChEBI ID: CHEMBL1175
  CAS Number: CAS 116539-59-4
  TTD Drug ID: D01AXB
  VARIDT Drug ID: DR01001
  INTEDE Drug ID: DR0554
  ACDINA Drug ID: D00220

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Vibrio cholerae infection	2.12	0.00e+0	44/50 (88%)	ATP6V1C1;ATP6V0C;ATP6V1B2;...
Epithelial cell signaling in Helicobacter pylori infect...	2.01	0.00e+0	62/70 (88.57%)	ATP6V1C1;PTPRZ1;MAPK13;...
Steroid biosynthesis	1.98	0.00e+0	19/20 (95%)	MSMO1;FDFT1;NSDHL;...
Collecting duct acid secretion	1.98	0.00e+0	22/27 (81.48%)	ATP6V1C1;ATP6V0C;ATP6V1B2;...
Terpenoid backbone biosynthesis	1.93	5.52e-3	18/22 (81.82%)	HMGCS1;IDI1;ACAT2;...
Basal cell carcinoma	1.88	1.38e-2	41/63 (65.08%)	FZD7;CDKN1A;GADD45B;...
IL-17 signaling pathway	1.87	1.38e-2	84/94 (89.36%)	S100A7;CEBPB;MAPK13;...
Cushing syndrome	1.79	2.59e-2	125/155 (80.65%)	FZD7;PDE8B;NR4A1;...
mTOR signaling pathway	1.76	3.22e-2	114/154 (74.03%)	FZD7;ATP6V1C1;LPIN1;...
Rheumatoid arthritis	1.76	3.04e-2	78/93 (83.87%)	ACP5;ATP6V1C1;ATP6V0C;...
Ferroptosis	1.76	2.76e-2	36/41 (87.8%)	HMOX1;PRNP;TFRC;...
Antigen processing and presentation	1.76	2.53e-2	60/78 (76.92%)	HSPA1A;CTSB;NFYB;...
Mucin type O-glycan biosynthesis	1.74	3.08e-2	20/36 (55.56%)	GALNT7;ST3GAL1;GALNT3;...
Melanogenesis	1.74	2.86e-2	74/101 (73.27%)	FZD7;EDNRB;GNAI1;...
Biosynthesis of unsaturated fatty acids	1.71	3.49e-2	21/27 (77.78%)	SCD;HACD1;ELOVL6;...
Protein processing in endoplasmic reticulum	1.71	3.36e-2	127/171 (74.27%)	HSPA1A;RAD23B;ERO1A;...
Pertussis	1.71	3.16e-2	64/76 (84.21%)	MAPK13;C1S;GNAI1;...
beta-Alanine metabolism	1.67	4.29e-2	25/30 (83.33%)	ALDH3A1;ALDH2;SMOX;...
Tuberculosis	1.66	4.57e-2	159/180 (88.33%)	CEBPB;MAPK13;ATP6V0C;...
Epstein-Barr virus infection	1.66	4.69e-2	189/202 (93.56%)	MAPK13;TNFAIP3;CYCS;...
Ribosome	-1.99	0.00e+0	113/158 (71.52%)	MRPS14;MRPL22;RPL35A;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 3.33uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼