Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM9BS50)

• Drug Name: Plumbagin Drug Info
• Synonyms: Plumbagin; 481-42-5; Plumbagine; 5-Hydroxy-2-methyl-1,4-naphthoquinone; Plumbaein; Plumbagone; 2-Methyljuglone; 5-hydroxy-2-methylnaphthalene-1,4-dione; 5-Hydroxy-2-methyl-1,4-naphthalenedione; 5-Hydroxy-2-methyl-[1,4]naphthoquinone; 1,4-Naphthalenedione, 5-hydroxy-2-methyl-; 2-Methyl-5-hydroxy-1,4-naphthoquinone; UNII-YAS4TBQ4OQ; NSC 688284; NSC 236613; CCRIS 6671; YAS4TBQ4OQ; EINECS 207-569-6; BRN 1870475; AI3-38055; CHEBI:8273; CHEMBL295316; VCMMXZQDRFWYSE-UHFFFAOYSA-N; 1,4-NAPHTHOQUINONE, 5-HYDROXY-2-METHYL-; NSC688284
• Cross-matching ID:
  PubChem CID: 10205
  ChEBI ID: CHEMBL8273
  CAS Number: CAS 481-42-5
  TTD Drug ID: D0P0IE
  VARIDT Drug ID: DR01476

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Nicotinate and nicotinamide metabolism	1.89	2.66e-2	25/35 (71.43%)	NAMPT;SIRT5;CD38;...
One carbon pool by folate	1.86	1.77e-2	15/20 (75%)	ATIC;MTHFD1;DHFR;...
Tyrosine metabolism	1.85	1.18e-2	30/36 (83.33%)	MIF;GOT1;FAH;...
Arginine biosynthesis	1.83	1.77e-2	17/22 (77.27%)	ASS1;GOT1;ARG1;...
Oxidative phosphorylation	1.78	2.84e-2	93/133 (69.92%)	ATP6V1E1;COX6B1;NDUFS8;...
Cytosolic DNA-sensing pathway	1.75	2.51e-2	52/63 (82.54%)	PYCARD;CCL4;CASP1;...
Arginine and proline metabolism	1.75	2.15e-2	39/50 (78%)	ODC1;AOC1;ALDH3A2;...
Primary bile acid biosynthesis	1.71	3.10e-2	15/17 (88.24%)	CYP39A1;SLC27A5;CYP27A1;...
Pancreatic secretion	-1.90	0.00e+0	87/102 (85.29%)	GNAQ;ADCY6;PNLIPRP1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Hide ▲