Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM9C1LQ)

Drug Name
GR-79236 Drug Info
Synonyms
GR79236; 124555-18-6; GR-79236; GR 79236; UNII-Q4H682B2VZ; GR 79236X; N-((1S,trans)-2-Hydroxycyclopentyl)adenosine; Q4H682B2VZ; CHEMBL2163568; N-((1S,2S)-2-Hydroxycyclopentyl)adenosine; N-[(1S, trans)-2-Hydroxycyclopentyl]adenosine; N-[(1S,2S)-2-Hydroxycyclopentyl]adenosine; N-[(1S,trans)-2-hydroxycyclopentyl]adenosine; Adenosine, N-(2-hydroxycyclopentyl)-, (1S-trans)-; gr79236x; SCHEMBL2779184; GTPL3288; CHEBI:92714; DTXSID10154427; MolPort-023-276-288; GYWXTRVEUURNEW-TVDBPQCTSA-N; HMS3268O08; ZINC3794575; MFCD00884605
Cross-matching ID
PubChem CID
9884817
ChEBI ID
CHEMBL2163568
CAS Number
CAS 124555-18-6
TTD Drug ID
D0V5DX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Complement and coagulation cascades 2.44 0.00e+0 76/85 (89.41%) C1R;SERPING1;CFI;...
Pertussis 2.05 5.23e-3 64/76 (84.21%) C1R;SERPING1;C2;...
Toll-like receptor signaling pathway 1.96 6.97e-3 94/104 (90.38%) CXCL9;CXCL10;CCL4;...
Chagas disease 1.86 2.61e-2 93/102 (91.18%) C3;C1QB;GNAQ;...
Progesterone-mediated oocyte maturation 1.86 2.09e-2 75/100 (75%) IGF1;CCNB1;CCNA2;...
T cell receptor signaling pathway 1.85 1.74e-2 93/104 (89.42%) NCK1;CD8A;NFATC3;...
Retinol metabolism 1.79 3.29e-2 41/68 (60.29%) CYP2C9;ALDH1A3;CYP2A6;...
Th17 cell differentiation 1.79 3.01e-2 95/107 (88.79%) IL6ST;HLA-DQB1;IL1RAP;...
Staphylococcus aureus infection 1.77 3.25e-2 72/95 (75.79%) C1R;CFI;HLA-DQB1;...
Renin-angiotensin system -1.71 4.54e-2 20/23 (86.96%) CTSG;ANPEP;THOP1;...
Pantothenate and CoA biosynthesis -1.72 4.10e-2 14/21 (66.67%) DPYD;AASDHPPT;ENPP1;...
Vibrio cholerae infection -1.73 4.62e-2 44/50 (88%) ATP6V0A1;ATP6V1C1;KDELR3;...
Diabetic cardiomyopathy -1.76 4.40e-2 162/203 (79.8%) NDUFB5;NDUFAB1;NDUFS4;...
Collecting duct acid secretion -1.78 4.78e-2 22/27 (81.48%) TCIRG1;SLC12A7;ATP6V1B2;...
Histidine metabolism -1.83 4.46e-2 16/22 (72.73%) MAOA;ALDH3A1;ALDH1B1;...
Oxidative phosphorylation -2.07 1.43e-2 93/133 (69.92%) NDUFB5;NDUFAB1;NDUFS4;...
Cardiac muscle contraction -2.07 1.91e-2 64/87 (73.56%) SLC9A7;TPM4;CACNB4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H