Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM9G3UD)

Drug Name
SQ-29548 Drug Info
Synonyms
7-(3-((2-((Phenylamino)carbonyl)hydrazino)methyl)-7-oxabicyclo(221)hept-2-yl)-5-heptenoic acid; SQ 28053; (Z)-7-[(1R,4S,5R,6R)-5-[(2-(phenylcarbamoyl)hydrazinyl)methyl]-7-oxabicyclo[221]heptan-6-yl]hept-5-enoic acid; 98672-91-4; 98299-61-7; [3H]SQ29548; SQ-28053; [3H]SQ-29548; [3H]-SQ29548; [3H]SQ-28053; GTPL1985; GTPL1980; 5-Heptenoic acid, 7-((1R,2R,3R,4S)-3-((2-((phenylamino)carbonyl)hydrazino)methyl)-7-oxabicyclo(221)hept-2-yl)-, (5Z)-rel-; 5-Heptenoic acid,
Cross-matching ID
PubChem CID
6437074
CAS Number
CAS 98299-61-7
TTD Drug ID
D02IBM

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Aminoacyl-tRNA biosynthesis 1.96 1.08e-2 15/66 (22.73%) DARS2;LARS2;GATC;...
Pantothenate and CoA biosynthesis 1.88 2.15e-2 14/21 (66.67%) AASDHPPT;COASY;ALDH3A2;...
Phototransduction -1.74 4.23e-2 21/29 (72.41%) SLC24A1;CALML4;PDE6A;...
Staphylococcus aureus infection -1.75 4.63e-2 72/95 (75.79%) KRT12;KRT32;PTAFR;...
Ferroptosis -1.81 2.96e-2 36/41 (87.8%) SLC7A11;LPCAT3;PCBP2;...
Cholesterol metabolism -1.93 4.63e-3 44/50 (88%) CYP27A1;STARD3;NPC1;...
Protein processing in endoplasmic reticulum -1.98 6.17e-3 127/171 (74.27%) HSP90AB1;PDIA3;NSFL1C;...
Mineral absorption -2.01 4.63e-3 48/60 (80%) HMOX2;ATP7B;MT2A;...
Thyroid hormone synthesis -2.13 0.00e+0 66/75 (88%) ADCY8;CREB3L1;SLC26A4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 1.11uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H