Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM9IUSM)

Drug Name
AS-604850 Drug Info
Synonyms AS 604850; PI 3-Kgamma inhibitor II
Cross-matching ID
PubChem CID
5287855
ChEBI ID
CHEMBL94690
TTD Drug ID
D03DRM

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Porphyrin and chlorophyll metabolism -1.71 4.89e-2 23/43 (53.49%) FECH;HCCS;PPOX;...
Estrogen signaling pathway -1.73 4.43e-2 119/137 (86.86%) KRT20;HSP90AB1;KRT9;...
Staphylococcus aureus infection -1.74 4.01e-2 72/95 (75.79%) ITGB2;DEFB1;ICAM1;...
Complement and coagulation cascades -1.75 4.02e-2 76/85 (89.41%) CFHR5;F13B;SERPINE1;...
Glyoxylate and dicarboxylate metabolism -1.77 3.61e-2 23/30 (76.67%) MDH1;AGXT;HAO1;...
Steroid biosynthesis -1.79 3.73e-2 19/20 (95%) HSD17B7;SOAT1;FDFT1;...
Pentose and glucuronate interconversions -1.80 3.89e-2 17/34 (50%) CRYL1;GUSB;AKR1A1;...
mTOR signaling pathway -1.80 3.46e-2 114/154 (74.03%) PIK3R2;PDPK1;DVL2;...
Cholesterol metabolism -1.81 4.15e-2 44/50 (88%) APOC3;LIPG;SORT1;...
Biosynthesis of unsaturated fatty acids -1.89 2.60e-2 21/27 (77.78%) ACOT7;ACOX3;HACD1;...
Mineral absorption -2.00 0.00e+0 48/60 (80%) ATP1B2;SLC39A4;TRPV6;...
Ferroptosis -2.23 0.00e+0 36/41 (87.8%) ATG7;VDAC3;SLC3A2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H