Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM9IZNP)

Drug Name
GSK-172981 Drug Info
Synonyms GSK-256471; SB-218795; SB-235375; SB-244487; SB-400238; SB-414240; SK-797230; NK-2 antagonists, GSK; NK-3 antagonists, GlaxoSmithKline; NK-3 antagonists, SB
Cross-matching ID
PubChem CID
25195091
ChEBI ID
CHEMBL480628
TTD Drug ID
D02CCA

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycolysis / Gluconeogenesis 2.05 0.00e+0 56/67 (83.58%) DLD;GPI;ALDOB;...
Galactose metabolism 1.99 4.41e-3 26/31 (83.87%) AKR1B10;PFKP;AKR1B1;...
DNA replication 1.91 1.18e-2 34/36 (94.44%) PCNA;RFC2;MCM7;...
Pentose phosphate pathway 1.81 3.75e-2 25/30 (83.33%) PGD;DERA;GPI;...
Fructose and mannose metabolism 1.78 3.88e-2 30/33 (90.91%) AKR1B10;ALDOB;PFKP;...
Mismatch repair 1.71 4.91e-2 22/23 (95.65%) PCNA;RFC2;SSBP1;...
Ferroptosis -1.92 7.51e-3 36/41 (87.8%) ACSL3;GCLM;NCOA4;...
Collecting duct acid secretion -1.99 5.63e-3 22/27 (81.48%) ATP6V1B2;ATP6V1E1;ATP6V0E1;...
Synaptic vesicle cycle -2.05 0.00e+0 63/78 (80.77%) AP2A2;ATP6V1B2;ATP6V1H;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H