Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM9J04X)

Drug Name
Butalbital Drug Info
Synonyms
Alisobumal; Alisobumalum; Allylbarbital; Allylbarbitone; Allylisobutylbarbital; Allylisobutylbarbiturate; Butalbarbital;Butalbitale; Butalbitalum; Itobarbital; Profundal; Sandoptal; Tetrallobarbital; Butalbitale [DCIT]; Axocet (TN); Axotal (TN); Bucet (TN); Bupap (TN); Butalbital [USAN:INN]; Butalbitalum [INN-Latin]; Cephadyn (TN); Dolgic (TN); Esgic (TN); Fioricet (TN); Fiorinal (TN); Fiormor (TN); Fiortal (TN); Fortabs (TN); IBS-L0126512; Iso-butylallylbarbituric acid; Laniroif (TN); Phrenilin (TN); Phrenilin Forte (TN); Sandoptal (TN); Sedapap (TN); Butalbital (USP/INN); Esgic-Plus (TN); 5-(2-methylpropyl)-5-(prop-2-en-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione; 5-(2-methylpropyl)-5-prop-2-en-1-ylpyrimidine-2,4,6(1H,3H,5H)-trione; 5-(2-methylpropyl)-5-prop-2-enyl-1,3-diazinane-2,4,6-trione; 5-Allyl-5-(2'-methyl-n-propyl) barbituric acid; 5-Allyl-5-(2-methylpropyl)barbituric acid; 5-Allyl-5-isobutyl-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-Allyl-5-isobutyl-pyrimidine-2,4,6-trione; 5-Allyl-5-isobutylbarbituric acid
Therapeutic ClassAnalgesics
Cross-matching ID
PubChem CID
2481
ChEBI ID
CHEMBL102524
CAS Number
CAS 77-26-9
TTD Drug ID
D05BQK

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Arachidonic acid metabolism -1.77 3.45e-2 48/61 (78.69%) GPX7;PLA2G4C;ALOX5;...
Pertussis -1.80 2.30e-2 64/76 (84.21%) FOS;MAPK3;IL1B;...
Pathogenic Escherichia coli infection -1.80 2.53e-2 152/197 (77.16%) FOS;CYTH2;MAPK3;...
TNF signaling pathway -1.84 1.72e-2 103/112 (91.96%) VEGFD;IL15;NFKBIA;...
Ferroptosis -1.86 1.15e-2 36/41 (87.8%) SLC39A8;TF;SLC7A11;...
IL-17 signaling pathway -1.91 1.15e-2 84/94 (89.36%) FOS;MAPK6;MAPK3;...
NF-kappa B signaling pathway -2.11 0.00e+0 90/104 (86.54%) TAB2;PIDD1;LTB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H