Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM9JXB7)

• Drug Name: Retapamulin Drug Info
• Synonyms: Altabax; Altargo; SB 275833; Altabax (Glaxo); Altabax (TN); Altargo (TN); Retapamulin (USAN/INN)
• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 6918462
  ChEBI ID: CHEMBL166679
  CAS Number: CAS 224452-66-8
  TTD Drug ID: D03UQM

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Oxidative phosphorylation	2.05	0.00e+0	93/133 (69.92%)	COX7A1;NDUFB5;ATP5F1C;...
Mineral absorption	2.02	0.00e+0	48/60 (80%)	MT1F;MT2A;MT1H;...
Parkinson disease	1.90	1.17e-2	176/249 (70.68%)	CYCS;GPR37;COX7A1;...
PPAR signaling pathway	1.85	2.63e-2	66/74 (89.19%)	FABP5;PCK1;PLIN2;...
Purine metabolism	1.76	4.39e-2	102/129 (79.07%)	PAPSS2;AK4;ADK;...
Citrate cycle (TCA cycle)	1.74	3.95e-2	30/30 (100%)	PCK1;DLD;IDH2;...
Tyrosine metabolism	1.74	3.51e-2	30/36 (83.33%)	ADH1B;ADH1C;ADH5;...
Fatty acid degradation	1.73	3.62e-2	40/43 (93.02%)	ADH1B;ADH1C;ADH5;...
Sulfur metabolism	1.69	4.78e-2	9/10 (90%)	PAPSS2;SQOR;PAPSS1;...
Pyruvate metabolism	1.68	4.74e-2	41/47 (87.23%)	ADH1B;PCK1;ACYP2;...
Prion disease	1.68	4.31e-2	209/273 (76.56%)	HSPA2;CYCS;COX7A1;...
Retinol metabolism	1.67	4.97e-2	41/68 (60.29%)	ADH1B;DHRS9;ADH1C;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.04uM - 10uM	24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼