Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM9JZ21)

Drug Name
Scriptaid Drug Info
Synonyms
CGK1026; IN1099; SB-556629; GNF-PF-2024; N-Hydroxy-1,3-dioxo-1H-benz(de)isoquinoline-2(3H)-hexan amide; 6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide; 6-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-hydroxyhexanamide; 6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide
Cross-matching ID
PubChem CID
5186
ChEBI ID
CHEMBL92401
CAS Number
CAS 287383-59-9
TTD Drug ID
D0J8OC

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Fructose and mannose metabolism 2.03 0.00e+0 30/33 (90.91%) ALDOC;ALDOB;AKR1B10;...
Carbohydrate digestion and absorption 2.02 0.00e+0 37/47 (78.72%) ATP1B1;PRKCB;SI;...
Aldosterone-regulated sodium reabsorption 2.02 0.00e+0 34/37 (91.89%) PRKCA;SGK1;ATP1B1;...
Mineral absorption 1.96 0.00e+0 48/60 (80%) SLC30A1;MT1X;ATP1B1;...
Synaptic vesicle cycle 1.95 0.00e+0 63/78 (80.77%) SLC1A1;STXBP1;ATP6V1D;...
Vibrio cholerae infection 1.93 3.64e-3 44/50 (88%) PRKCA;ADCY9;ATP6V1D;...
Insulin secretion 1.91 3.12e-3 75/86 (87.21%) PRKCA;ADCY9;ATP1B1;...
Collecting duct acid secretion 1.82 1.64e-2 22/27 (81.48%) ATP6V1D;CA2;ATP6V1C1;...
Proximal tubule bicarbonate reclamation 1.80 1.94e-2 21/23 (91.3%) ATP1B1;CA2;MDH1;...
Citrate cycle (TCA cycle) 1.79 2.07e-2 30/30 (100%) IDH1;IDH3A;DLD;...
Gastric acid secretion 1.79 1.98e-2 63/76 (82.89%) GNAI2;PRKCA;ADCY9;...
Aldosterone synthesis and secretion 1.75 3.18e-2 85/98 (86.73%) PRKCA;ADCY9;AGT;...
Terpenoid backbone biosynthesis 1.73 3.86e-2 18/22 (81.82%) IDI1;HMGCS1;PCYOX1;...
Glycerophospholipid metabolism 1.68 4.84e-2 71/98 (72.45%) PLA2G15;GPD1L;PLA2G2A;...
Fat digestion and absorption 1.68 4.56e-2 35/43 (81.4%) PLA2G2A;FABP1;CD36;...
Steroid biosynthesis 1.68 4.30e-2 19/20 (95%) LIPA;MSMO1;TM7SF2;...
Propanoate metabolism 1.68 4.08e-2 30/34 (88.24%) ABAT;HIBCH;DLD;...
Cortisol synthesis and secretion 1.67 4.25e-2 58/65 (89.23%) ADCY9;AGT;PRKACB;...
Pyruvate metabolism 1.67 4.10e-2 41/47 (87.23%) DLD;MDH1;AKR1A1;...
Endocrine and other factor-regulated calcium reabsorpti... 1.65 4.81e-2 49/53 (92.45%) PRKCA;ADCY9;ATP1B1;...
Cushing syndrome 1.64 4.88e-2 125/155 (80.65%) GNAI2;ADCY9;AGT;...
One carbon pool by folate -2.11 0.00e+0 15/20 (75%) MTHFD2;GART;MTHFD2L;...
IL-17 signaling pathway -2.36 0.00e+0 84/94 (89.36%) TRAF2;PTGS2;TRAF3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 10uM 6H, 24H
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H