Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM9M3VC)

Drug Name
Ki-20227 Drug Info
Synonyms Ki 20227; Ki20227
Cross-matching ID
PubChem CID
9869779
ChEBI ID
CHEMBL1908396
CAS Number
CAS 623142-96-1
TTD Drug ID
D08BJR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.10 0.00e+0 113/158 (71.52%) MRPL20;RPL10;RPS4Y1;...
Glutathione metabolism 2.02 0.00e+0 43/57 (75.44%) GSTT1;GPX3;GPX7;...
Steroid hormone biosynthesis 1.87 1.68e-2 43/61 (70.49%) AKR1C3;AKR1C2;AKR1C1;...
Arachidonic acid metabolism 1.81 2.70e-2 48/61 (78.69%) AKR1C3;PTGIS;PLA2G2A;...
Terpenoid backbone biosynthesis 1.81 2.16e-2 18/22 (81.82%) ACAT2;IDI1;FDPS;...
Allograft rejection 1.79 2.28e-2 32/38 (84.21%) HLA-F;HLA-C;HLA-G;...
Proteasome 1.73 3.08e-2 44/46 (95.65%) PSMB8;PSMA3;PSMA4;...
N-Glycan biosynthesis 1.70 3.77e-2 38/50 (76%) DPM3;DDOST;DPAGT1;...
Fatty acid elongation 1.67 4.15e-2 19/27 (70.37%) ELOVL6;ACAA2;HADH;...
DNA replication 1.65 4.24e-2 34/36 (94.44%) POLE2;FEN1;SSBP1;...
Fatty acid degradation 1.64 4.51e-2 40/43 (93.02%) ACAT2;ACSL1;ALDH2;...
Base excision repair 1.63 4.73e-2 29/33 (87.88%) POLE2;FEN1;SMUG1;...
Retinol metabolism 1.63 4.48e-2 41/68 (60.29%) ALDH1A1;CYP3A5;AOX1;...
Spliceosome 1.61 4.72e-2 101/150 (67.33%) LSM5;SNRPE;SNRPD1;...
MAPK signaling pathway -1.64 4.24e-2 272/294 (92.52%) PRKACA;ERBB4;FGFR3;...
Inflammatory mediator regulation of TRP channels -1.65 3.87e-2 82/98 (83.67%) MAPK8;ADCY8;CAMK2B;...
Platelet activation -1.65 3.87e-2 106/124 (85.48%) ADCY8;PTGIR;P2RY1;...
Sulfur metabolism -1.66 3.74e-2 9/10 (90%) MPST;ETHE1;SELENBP1;...
Fc gamma R-mediated phagocytosis -1.66 3.88e-2 79/97 (81.44%) LIMK1;DOCK1;ARPC4;...
Glutamatergic synapse -1.67 3.68e-2 97/114 (85.09%) GRIA2;GNAI3;GNG3;...
Regulation of actin cytoskeleton -1.67 3.78e-2 185/218 (84.86%) PIP4K2B;PIP4K2C;ITGA8;...
Renin secretion -1.67 3.67e-2 61/69 (88.41%) KCNMA1;ITPR2;EDN2;...
Salmonella infection -1.68 3.67e-2 198/249 (79.52%) IKBKB;IL18;MYO6;...
Cholinergic synapse -1.69 3.00e-2 99/113 (87.61%) ADCY8;CAMK2B;GNAI3;...
Leukocyte transendothelial migration -1.70 3.09e-2 90/114 (78.95%) PLCG2;CTNNA1;PLCG1;...
Bile secretion -1.72 2.59e-2 68/90 (75.56%) ATP1A3;SLC9A3;ABCG2;...
Proteoglycans in cancer -1.76 1.89e-2 172/205 (83.9%) RRAS2;TP53;ITPR1;...
Shigellosis -1.76 1.93e-2 180/246 (73.17%) RAC1;TLR4;ARF1;...
Circadian entrainment -1.77 1.89e-2 85/97 (87.63%) PER2;ADCY8;CAMK2B;...
Morphine addiction -1.78 1.60e-2 80/91 (87.91%) ARRB2;GABRP;GABBR2;...
Amoebiasis -1.79 1.62e-2 99/102 (97.06%) PRKACA;SERPINB4;SERPINB6;...
Insulin secretion -1.80 1.55e-2 75/86 (87.21%) KCNMA1;RYR2;ATP1A3;...
HIF-1 signaling pathway -1.80 1.58e-2 105/109 (96.33%) IFNGR1;IL6;EGLN3;...
Salivary secretion -1.83 1.15e-2 76/93 (81.72%) DMBT1;MUC7;ATP2B1;...
Rap1 signaling pathway -1.85 7.56e-3 184/210 (87.62%) TLN1;FGFR3;PDGFRB;...
ECM-receptor interaction -1.88 2.80e-3 80/88 (90.91%) COL4A2;GP1BB;COL6A3;...
Focal adhesion -1.88 1.58e-3 180/201 (89.55%) TLN1;PDGFRB;PIK3R1;...
Gastric acid secretion -1.88 1.80e-3 63/76 (82.89%) ADCY8;CAMK2B;GNAI3;...
AGE-RAGE signaling pathway in diabetic complications -1.89 2.10e-3 97/100 (97%) PIK3R1;COL4A2;BCL2;...
Bacterial invasion of epithelial cells -1.92 2.52e-3 59/77 (76.62%) PIK3R2;ELMO3;ACTB;...
Aldosterone-regulated sodium reabsorption -1.95 3.15e-3 34/37 (91.89%) ATP1A3;SFN;ATP1B3;...
VEGF signaling pathway -1.96 4.20e-3 50/59 (84.75%) RAC1;SH2D2A;PIK3R1;...
Apelin signaling pathway -1.99 6.30e-3 117/137 (85.4%) SERPINE1;PRKAB1;EGR1;...
Proximal tubule bicarbonate reclamation -2.16 0.00e+0 21/23 (91.3%) ATP1A3;SLC9A3;ATP1B3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H