Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM9VDZP)

Drug Name
CGP-53353 Drug Info
Synonyms
145915-60-2; CGP 53353; CGP-53353; DAPH 2; DAPH-7; CGP53353; PKCbetaII/EGFR Inhibitor; 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE; CHEMBL7939; CGP 53 353; 4,5-bis(4-Fluoroanilino)-phthalimide; CG53353; 5,6-Bis((4-fluorophenyl)amino)isoindoline-1,3-dione; 5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione; 4,5-Bis(4-fluoroanilino)phthalimide; 4,5-Bis[4-fluoroanilino]phthalimide; PKCbII/EGFR Inhibitor; AC1O8KXF; 5,6-bis(4-fluoroanilino)isoindole-1,3-dione; MolMap_000016; DAPH-2; CGP-53353, solid; SCHEMBL230492
Cross-matching ID
PubChem CID
6711154
ChEBI ID
CHEMBL7939
CAS Number
CAS 145915-60-2
TTD Drug ID
D0HO1S

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Malaria 2.09 0.00e+0 44/50 (88%) MET;THBS2;GYPC;...
ECM-receptor interaction 2.05 0.00e+0 80/88 (90.91%) THBS2;ITGA6;RELN;...
TGF-beta signaling pathway 1.87 1.37e-2 81/94 (86.17%) ID1;TGFBR2;BMP4;...
Ribosome 1.85 1.03e-2 113/158 (71.52%) RPS27L;MRPL15;MRPS2;...
Pertussis -1.71 4.42e-2 64/76 (84.21%) CASP3;C3;TNF;...
Tryptophan metabolism -1.77 2.13e-2 35/42 (83.33%) AOC1;DHTKD1;AOX1;...
Propanoate metabolism -1.81 1.79e-2 30/34 (88.24%) ALDH6A1;ACOX1;ACACA;...
beta-Alanine metabolism -1.87 1.33e-2 25/30 (83.33%) ALDH6A1;ACOX1;HIBCH;...
Peroxisome -1.91 1.14e-2 72/82 (87.8%) MLYCD;DDO;GNPAT;...
Nitrogen metabolism -1.93 1.14e-2 16/17 (94.12%) GLUL;CPS1;CA2
Biosynthesis of unsaturated fatty acids -1.95 1.52e-2 21/27 (77.78%) SCD;ELOVL6;ACOT7;...
Histidine metabolism -1.96 1.70e-2 16/22 (72.73%) ASPA;MAOB;AOC1;...
Terpenoid backbone biosynthesis -2.05 1.14e-2 18/22 (81.82%) PDSS2;PCYOX1;PMVK;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 2.5uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 2.5uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H