Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM9WLN4)

Drug Name
10-hydroxycamptothecin Drug Info
Synonyms
10-Hydroxycamptothecin; 19685-09-7; (S)-10-Hydroxycamptothecin; Hydroxycamptothecin; 10-hydroxycamptothecine; 10-Hydroxy camptothecin; Hydroxycamptothecine; Camptothecin, hydroxy-; 10-Hydroxy-Camptothecin; (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Camptothecin, 10-hydroxy-; Camptothecine, 10-hydroxy-; UNII-9Z01632KRV; NSC 107124; HCPT; (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (S)-10-Hydroxycamptothecin hydrate; NSC107124
Cross-matching ID
PubChem CID
97226
ChEBI ID
CHEMBL273862
CAS Number
CAS 19685-09-7
TTD Drug ID
D07ILP
VARIDT Drug ID
DR01489

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Spliceosome 2.33 0.00e+0 101/150 (67.33%) SNRPG;HNRNPM;SRSF3;...
Ribosome 2.06 7.12e-3 113/158 (71.52%) MRPS16;MRPL13;MRPL19;...
Proteasome 1.99 4.75e-3 44/46 (95.65%) PSMC6;PSMB5;PSMD12;...
RNA transport 1.88 8.90e-3 128/186 (68.82%) EIF3H;EIF5;SUMO3;...
RNA degradation 1.88 7.12e-3 53/79 (67.09%) BTG3;CNOT4;EXOSC8;...
Cell cycle 1.71 3.44e-2 110/124 (88.71%) CDC20;TGFB1;TFDP1;...
Fatty acid biosynthesis -1.72 4.31e-2 16/18 (88.89%) ACSBG1;ACACB;HSD17B8;...
Valine, leucine and isoleucine degradation -1.72 4.79e-2 42/48 (87.5%) ACAT1;ALDH6A1;MMUT;...
Phenylalanine metabolism -1.80 4.18e-2 14/17 (82.35%) AOC3;GOT1;MAOB;...
Phosphatidylinositol signaling system -1.88 2.94e-2 82/97 (84.54%) DGKI;PIK3C2A;PLCD1;...
Mineral absorption -1.89 3.49e-2 48/60 (80%) ATP1A3;MT1HL1;FTH1;...
Histidine metabolism -2.01 3.27e-2 16/22 (72.73%) ALDH2;ALDH3A2;HAL;...
Glycine, serine and threonine metabolism -2.13 0.00e+0 31/40 (77.5%) PHGDH;AOC3;SHMT2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H