Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM9Y6X7)

• Drug Name: Clodronate Drug Info
• Synonyms: Bonefos; Clodronsaeure; Dichloromethanediphosphonate; Dichloromethylenebisphosphonate; Methanedichlorodiphosphonate; Acide clodronique; Acido clodronico; Acidum clodronicum; Clodronic Acid; Dichloromethanediphosphonic acid; Dichloromethylene Biphosphonate; Dichloromethylene Diphosphonate; Dichloromethylidene diphosphonate; Liposomes containing clodronic acid; Methanedichlorodiphosphonic acid; Acid, Clodronic; Acid, Dichloromethanediphosphonic; Acide clodronique [INN-French]; Acido clodronico [INN-Spanish]; Acidum clodronicum [INN-Latin]; Biphosphonate, Dichloromethylene; Bonefos (TN); Clodron (TN); Diphosphonate, Dichloromethane; Diphosphonate, Dichloromethylene; Disodium, Clodronate; Loron (TN); Sodium, Clodronate; [dichloro(phosphono)methyl]phosphonic acid; Clodronic acid (USAN/INN); Clodronic acid [USAN:BAN:INN]; Dichlormethylen-bis(phosphonsaeure); Dichloromethylene-1,1-bisphosphonic acid; Dichloromethylene-1,1-diphosphonic acid; Phosphonic acid, (dichloromethylene)di-(8CI); (Dichloro-phosphono-methyl)-phosphonic acid; (Dichloromethylene)bisphosphonic acid; (Dichloromethylene)diphosphonic acid; (Lip-C); (dichloromethanediyl)bis(phosphonic acid)
• Therapeutic Class: Antihypocalcemic Agents
• Cross-matching ID:
  PubChem CID: 25419
  ChEBI ID: CHEMBL12318
  CAS Number: CAS 10596-23-3
  TTD Drug ID: D00HNB
  VARIDT Drug ID: DR00994

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Homologous recombination	2.05	0.00e+0	35/41 (85.37%)	TOPBP1;RPA3;MRE11;...
African trypanosomiasis	-1.74	4.88e-2	32/37 (86.49%)	THOP1;TNF;VCAM1;...
Collecting duct acid secretion	-1.78	3.81e-2	22/27 (81.48%)	CLCNKB;ATP6V1G1;ATP6V1D;...
HIF-1 signaling pathway	-1.80	4.68e-2	105/109 (96.33%)	LDHB;PFKM;CAMK2B;...
Mineral absorption	-2.31	0.00e+0	48/60 (80%)	ATP2B1;SLC30A1;VDR;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	12.5uM	72H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼