Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM9YSNQ)

• Drug Name: Amfepramone Drug Info
• Synonyms: Diethylpropion; DIETHYLPROPION; Diethylpropione; Amfepramon; Tepanil; Anorex; Nopropiophenone; Frekentine; Amphepramon; Amfepramonum; Amphepramone; Adiposon; Tylinal; Magrene; Dobesin; Neobes; Danylen; alpha-Benzoyltriethylamine; Anfepramona; Cegramine; Obesitex; Silutin; Regenon; Prefamone; Derfon; alpha-Diethylaminopropiophenone; 90-84-6; Diethylcathinone; Amfepramonum [INN-Latin]; Anfepramona [INN-Spanish]; Amfepramone [INN]; Parabolin; Modulor; Keramik; Keramin; Anfamon; 2-(Diethylamino)propiophenone; 1-Phenyl-2-diethylamino-1-propanone; Adiposon; Danylen;Derfon; Phepranon; Reginon; Amfepramone HCL; Amfepramone hydrochloride; Amphepramonum hydrochloride; Diethylpropion HCL; Diethylpropione hydrochloride; Tenuate hydrochloride; UR 1423; Alpha-Benzoyltriethylamine; Alpha-Diethylaminopropiophenone; Amfepramone (INN); Diethylpropion (BAN); Fenyl-(1-diethylaminoethyl)keton; Fenyl-(1-diethylaminoethyl)keton [Czech]; (+-)-diethylpropion; 2-(Diethylamino)-1-phenyl-1-propanone; 2-(diethylamino)-1-phenylpropan-1-one; 2-Diethylaminopropiophenone
• Cross-matching ID:
  PubChem CID: 7029
  ChEBI ID: CHEMBL4530
  CAS Number: CAS 90-84-6
  TTD Drug ID: D0B7OD
  VARIDT Drug ID: DR01090
  ACDINA Drug ID: D00196

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.44	0.00e+0	34/36 (94.44%)	PCNA;FEN1;MCM5;...
Mismatch repair	2.03	0.00e+0	22/23 (95.65%)	PCNA;MLH1;RFC4;...
Base excision repair	1.93	2.95e-3	29/33 (87.88%)	PCNA;FEN1;POLE2;...
Spliceosome	1.88	8.85e-3	101/150 (67.33%)	PUF60;EIF4A3;PRPF4;...
Protein export	1.82	1.59e-2	17/23 (73.91%)	OXA1L;SRPRA;SEC61G;...
Cell cycle	1.80	1.62e-2	110/124 (88.71%)	PCNA;CCNB2;MCM5;...
Ribosome biogenesis in eukaryotes	1.76	2.40e-2	52/108 (48.15%)	NVL;IMP3;POP5;...
Pyrimidine metabolism	1.71	3.32e-2	40/56 (71.43%)	TYMS;RRM2;RRM1;...
Fanconi anemia pathway	1.69	3.64e-2	36/54 (66.67%)	MLH1;FANCG;FANCI;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼