Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM9ZBLE)

Drug Name
sphinganine Drug Info
Synonyms dihydrosphingosine; dihydro-D-erythrosphingosine
Cross-matching ID
PubChem CID
91486
ChEBI ID
CHEMBL448741
CAS Number
CAS 764-22-7
TTD Drug ID
D06ATM
VARIDT Drug ID
DR01364

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Asthma 1.98 0.00e+0 25/31 (80.65%) HLA-DPA1;HLA-DQB1;CD40;...
Rheumatoid arthritis 1.92 5.80e-3 78/93 (83.87%) CXCL2;ACP5;HLA-DPA1;...
Intestinal immune network for IgA production 1.92 3.86e-3 38/48 (79.17%) HLA-DPA1;HLA-DQB1;CD40;...
Viral protein interaction with cytokine and cytokine re... 1.90 2.90e-3 84/100 (84%) CXCL13;CXCL9;CXCL2;...
Chemokine signaling pathway 1.84 9.27e-3 163/192 (84.9%) CXCL13;CXCL9;CXCL2;...
RNA polymerase 1.84 7.73e-3 23/31 (74.19%) POLR2D;POLR2L;POLR2I;...
NF-kappa B signaling pathway 1.80 1.49e-2 90/104 (86.54%) RELB;CXCL2;CCL19;...
DNA replication 1.73 4.49e-2 34/36 (94.44%) MCM5;RNASEH2B;POLA2;...
Systemic lupus erythematosus 1.73 4.12e-2 45/135 (33.33%) C1QA;HLA-DPA1;C1QB;...
Cytokine-cytokine receptor interaction 1.72 3.71e-2 246/295 (83.39%) CXCL13;CXCL9;CXCL2;...
Mineral absorption -1.79 4.73e-2 48/60 (80%) ATP7B;SLC11A2;SLC26A6;...
Thyroid cancer -1.85 2.86e-2 36/37 (97.3%) GADD45G;TCF7;RXRA;...
Cholesterol metabolism -1.86 3.87e-2 44/50 (88%) LIPA;ANGPTL3;VDAC2;...
PPAR signaling pathway -2.11 0.00e+0 66/74 (89.19%) ACOX1;PCK2;UBC;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.001uM - 1.11uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.001uM - 1.11uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.001uM - 1.11uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.001uM - 1.11uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.001uM - 1.11uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.001uM - 1.11uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.001uM - 1.11uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.001uM - 1.11uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.001uM - 1.11uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.001uM - 1.11uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.001uM - 1.11uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.001uM - 1.11uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.001uM - 1.11uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.004uM - 1.11uM 24H