Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM9ZMQH)

• Drug Name: Clocortolone Drug Info
• Synonyms: Clocortolona; Clocortolonum; Clocortolone (INN); (6S,8S,9R,10S,11S,13S,14S,16R,17S)-9-chloro-6-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one; 9-chloro-6alpha-fluoro-11beta,21-dihydroxy-16alpha-methyl-1,4-pregnadien-3,20-dione; 9-chloro-6alpha-fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione; 9-chloro-6alpha-fluoro-16alpha-methyl-1,4-pregnadiene-11beta,21-diol-3,20-dione
• Cross-matching ID:
  PubChem CID: 5311052
  ChEBI ID: CHEMBL59582
  CAS Number: CAS 4828-27-7
  TTD Drug ID: D00GOS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Protein digestion and absorption	2.15	0.00e+0	78/103 (75.73%)	COL6A3;COL5A2;COL1A2;...
Nitrogen metabolism	1.88	2.24e-2	16/17 (94.12%)	CA2;CA3;CA12;...
Cardiac muscle contraction	1.86	1.86e-2	64/87 (73.56%)	MYL2;TNNC1;TPM3;...
Arginine and proline metabolism	1.84	1.40e-2	39/50 (78%)	CKM;ODC1;CKMT2;...
Dilated cardiomyopathy	1.82	1.34e-2	86/96 (89.58%)	MYL2;TNNC1;TTN;...
Hypertrophic cardiomyopathy	1.78	3.54e-2	81/90 (90%)	MYL2;TNNC1;TTN;...
NOD-like receptor signaling pathway	-1.73	4.44e-2	145/181 (80.11%)	TICAM1;TAB2;STAT2;...
Leishmaniasis	-1.76	4.62e-2	67/77 (87.01%)	MAPK3;TNF;IFNGR2;...
Legionellosis	-1.80	3.11e-2	51/57 (89.47%)	TNF;TLR5;CASP7;...
Staphylococcus aureus infection	-1.80	4.14e-2	72/95 (75.79%)	SELPLG;HLA-DMB;HLA-DQA1;...
IL-17 signaling pathway	-1.86	2.22e-2	84/94 (89.36%)	IKBKB;CXCL2;FOS;...
Complement and coagulation cascades	-1.99	8.88e-3	76/85 (89.41%)	MASP2;FGA;MBL2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲