Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMA04JS)

• Drug Name: Antazoline Drug Info
• Synonyms: Analergine; Antastan; Antasten; Antazolin; Antazolina; Antazolinum; Antihistal; Antistin; Antistine; Azalone; Histostab;Imidamin; Imidamine; Phenazolin; Phenazoline; Antazolina [Spanish]; Antazolinum [Latin]; Antazolina [INN-Spanish]; Antazoline (INN); Antazoline [INN:BAN]; Antazolinum [INN-Latin]; Ben-A-hist; N-Benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline; N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-N-(phenylmethyl)aniline; 2-(N-Benzylanilinomethyl)-2-imidazoline; 2-(N-Phenyl-N-benzylaminomethyl)imidazoline; 2-Phenyl-benzyl-amino-methylimidazolin; 2-Phenyl-benzyl-amino-methylimidazolin [German]; 4,5-Dihydro-N-phenyl-N-phenylmethyl-1H-imidazole-2-methanamine; 5512-M
• Cross-matching ID:
  PubChem CID: 2200
  ChEBI ID: CHEMBL84115
  CAS Number: CAS 91-75-8
  TTD Drug ID: D06FZX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Ribosome	1.96	3.92e-2	113/158 (71.52%)	RPS4Y1;MRPS16;MRPL23;...
Cardiac muscle contraction	1.89	4.90e-2	64/87 (73.56%)	ATP2A2;TPM2;CACNA1D;...
Other types of O-glycan biosynthesis	1.84	3.27e-2	29/47 (61.7%)	GALNT14;EOGT;GALNT3;...
Homologous recombination	1.82	3.68e-2	35/41 (85.37%)	RAD51C;RBBP8;MRE11;...
Autoimmune thyroid disease	-1.65	4.53e-2	46/53 (86.79%)	HLA-G;HLA-DPA1;CTLA4;...
Th1 and Th2 cell differentiation	-1.67	4.21e-2	80/92 (86.96%)	HLA-DOA;MAPK1;CD247;...
Type I diabetes mellitus	-1.68	4.01e-2	38/43 (88.37%)	LTA;HLA-DOA;INS;...
Glycine, serine and threonine metabolism	-1.69	3.77e-2	31/40 (77.5%)	AMT;ALAS1;GLDC;...
Valine, leucine and isoleucine degradation	-1.70	3.40e-2	42/48 (87.5%)	BCKDHA;HMGCS2;ACAT1;...
Fatty acid degradation	-1.72	3.15e-2	40/43 (93.02%)	ACAT1;ACADL;HADHB;...
Fatty acid elongation	-1.73	3.06e-2	19/27 (70.37%)	MECR;PPT2;HSD17B12;...
Tyrosine metabolism	-1.74	3.17e-2	30/36 (83.33%)	ADH1A;TYR;GOT2;...
Linoleic acid metabolism	-1.75	3.19e-2	21/29 (72.41%)	ALOX15;PLA2G1B;PLAAT3;...
Proximal tubule bicarbonate reclamation	-1.76	3.35e-2	21/23 (91.3%)	GLS2;PCK2;GLS;...
Pentose phosphate pathway	-1.80	2.89e-2	25/30 (83.33%)	PGLS;H6PD;ALDOC;...
Arginine and proline metabolism	-1.84	2.04e-2	39/50 (78%)	DAO;CKMT2;PYCR1;...
Cell adhesion molecules	-1.89	7.65e-3	118/148 (79.73%)	ICOSLG;CLDN4;HLA-G;...
Allograft rejection	-2.02	0.00e+0	32/38 (84.21%)	HLA-G;HLA-DPA1;HLA-F;...
Mineral absorption	-2.04	0.00e+0	48/60 (80%)	HMOX1;ATP2B4;VDR;...
Tryptophan metabolism	-2.17	0.00e+0	35/42 (83.33%)	CYP1B1;ACAT2;DDC;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	24H	Hide ▲