Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMA0DSJ)

Drug Name
L-694,458 Drug Info
Synonyms
DMP 777; 157341-41-8; DMP-777; UNII-3Q0469283P; (S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4-methylpiperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxamide; DMP777; CHEMBL310871; L-694458; 3Q0469283P; (S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxamide (3.5% w/w solution); L-694,458; L 694458; SCHEMBL6538142; AC1L433D; CTK4C9348; DTXSID00166251; MolPort-023-332-820; C31H40N4O6; ZINC3936307; KS-00001E6Q; BCP02269
Cross-matching ID
PubChem CID
177992
ChEBI ID
CHEMBL310871
CAS Number
CAS 157341-41-8
TTD Drug ID
D08PBB

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.14 0.00e+0 113/158 (71.52%) MRPS16;RPL26L1;RPS26;...
Oxidative phosphorylation 2.03 0.00e+0 93/133 (69.92%) COX7B;NDUFB1;ATP5F1C;...
Parkinson disease 1.98 0.00e+0 176/249 (70.68%) DAXX;TUBB2A;UCHL1;...
Tyrosine metabolism 1.80 2.43e-2 30/36 (83.33%) TYRP1;GSTZ1;TYR;...
DNA replication 1.75 4.04e-2 34/36 (94.44%) PRIM1;POLE2;RNASEH2A;...
Nucleotide excision repair 1.73 4.49e-2 40/47 (85.11%) POLE2;RFC4;RPA3;...
Mineral absorption 1.71 4.49e-2 48/60 (80%) TF;STEAP1;MT1F;...
Thiamine metabolism 1.71 4.11e-2 12/15 (80%) AK4;AK5;ACP1
Human papillomavirus infection -1.83 1.61e-2 284/331 (85.8%) TCIRG1;ATP6V0C;TSC1;...
Asthma -1.84 1.39e-2 25/31 (80.65%) HLA-DQB1;MS4A2;EPX;...
Protein processing in endoplasmic reticulum -1.85 1.55e-2 127/171 (74.27%) SIL1;HSP90B1;NPLOC4;...
Rheumatoid arthritis -1.91 6.33e-3 78/93 (83.87%) ATP6V1C1;TLR2;TNF;...
Malaria -1.93 3.61e-3 44/50 (88%) LRP1;TLR2;TNF;...
Staphylococcus aureus infection -1.95 2.11e-3 72/95 (75.79%) C5;CFD;FPR3;...
Notch signaling pathway -1.98 2.53e-3 49/59 (83.05%) NCOR2;PSEN2;KAT2A;...
Focal adhesion -1.99 3.16e-3 180/201 (89.55%) PAK2;ITGA2;PDGFD;...
Legionellosis -2.06 4.22e-3 51/57 (89.47%) HSPA6;HSPA8;CD14;...
Amoebiasis -2.19 0.00e+0 99/102 (97.06%) NOS2;LAMA4;PRKCG;...
ECM-receptor interaction -2.33 0.00e+0 80/88 (90.91%) THBS4;COL4A4;ITGA7;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 2.22uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H