Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMA2GHJ)

Drug Name
Tolperisone Drug Info
Synonyms Agileo; Viveo; AV-650; SPH-3047; Tolperisone (controlled-release); Tolperisone (controlled-release), Sanochemia; Tolperisone (controlled-release), Sanochemia/Avigen
Cross-matching ID
PubChem CID
5511
ChEBI ID
CHEMBL93835
CAS Number
CAS 728-88-1
TTD Drug ID
D0X0WU
INTEDE Drug ID
DR1614

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Systemic lupus erythematosus 2.17 0.00e+0 45/135 (33.33%) C3;FCGR2A;CD40;...
Staphylococcus aureus infection 1.89 1.81e-2 72/95 (75.79%) C3;FCGR2A;KRT18;...
Cell cycle 1.87 1.61e-2 110/124 (88.71%) CDC20;CDKN2A;E2F2;...
Viral myocarditis 1.85 1.21e-2 53/60 (88.33%) CD40;BID;HLA-DPA1;...
Allograft rejection 1.84 9.67e-3 32/38 (84.21%) CD40;HLA-DPA1;GZMB;...
Type I diabetes mellitus 1.83 1.01e-2 38/43 (88.37%) CPE;HLA-DPA1;GZMB;...
Toxoplasmosis 1.81 1.73e-2 103/112 (91.96%) HSPA8;CD40;HLA-DPA1;...
African trypanosomiasis 1.81 1.66e-2 32/37 (86.49%) APOA1;PLCB1;PRKCB;...
Viral carcinogenesis 1.80 1.88e-2 149/203 (73.4%) USP7;C3;CDC20;...
Asthma 1.78 1.93e-2 25/31 (80.65%) CD40;HLA-DPA1;HLA-DQB1;...
Small cell lung cancer 1.71 4.62e-2 90/92 (97.83%) ITGAV;COL4A5;E2F2;...
Graft-versus-host disease 1.70 4.64e-2 32/42 (76.19%) HLA-DPA1;GZMB;HLA-DQB1;...
Leishmaniasis 1.69 4.37e-2 67/77 (87.01%) C3;FCGR2A;PRKCB;...
p53 signaling pathway 1.67 4.84e-2 63/73 (86.3%) CDKN2A;CCND2;BID;...
Pentose and glucuronate interconversions -1.88 2.57e-2 17/34 (50%) UGT2B15;UGDH;AKR1B10;...
Ribosome -1.98 3.85e-3 113/158 (71.52%) RPL12;RPL4;MRPS2;...
Metabolism of xenobiotics by cytochrome P450 -2.04 0.00e+0 49/77 (63.64%) MGST3;ALDH3B1;GSTM5;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H