Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMA2K7C)

Drug Name
Donitriptan Drug Info
Synonyms Donitriptan mesylate; F-11356; F-12640; Migraine therapy, Pierre Fabre; 5-HT1D agonist, Pierre Fabre
Cross-matching ID
PubChem CID
197706
CAS Number
CAS 170912-52-4
TTD Drug ID
D0G5ML

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Th17 cell differentiation 2.08 0.00e+0 95/107 (88.79%) NFATC3;IL2RG;HLA-DQA1;...
T cell receptor signaling pathway 1.93 1.98e-2 93/104 (89.42%) NFATC3;MAPK1;PIK3R1;...
PD-L1 expression and PD-1 checkpoint pathway in cancer 1.91 1.76e-2 79/89 (88.76%) NFATC3;MAPK1;PIK3R1;...
Nucleotide excision repair 1.89 1.98e-2 40/47 (85.11%) RAD23B;MNAT1;RFC4;...
Primary bile acid biosynthesis 1.85 2.64e-2 15/17 (88.24%) AMACR;CYP46A1;SLC27A5;...
Lysine degradation 1.72 4.83e-2 51/63 (80.95%) SMYD2;BBOX1;MECOM;...
Folate biosynthesis -1.66 4.67e-2 23/26 (88.46%) MOCS1;TPH1;SPR;...
Steroid hormone biosynthesis -1.71 2.82e-2 43/61 (70.49%) CYP21A2;CYP3A7;HSD3B1;...
SNARE interactions in vesicular transport -1.72 2.92e-2 19/33 (57.58%) STX4;SNAP29;SNAP23;...
Fat digestion and absorption -1.72 3.24e-2 35/43 (81.4%) PLA2G2A;NPC1L1;PLA2G10;...
ABC transporters -1.72 3.78e-2 37/45 (82.22%) ABCC8;ABCA4;ABCA2;...
Protein digestion and absorption -1.77 2.75e-2 78/103 (75.73%) COL21A1;SLC7A8;CPA1;...
Porphyrin and chlorophyll metabolism -1.78 3.26e-2 23/43 (53.49%) CPOX;HMBS;COX10;...
Glycerolipid metabolism -1.81 2.52e-2 44/61 (72.13%) PNLIP;PNLIPRP2;GK2;...
Complement and coagulation cascades -1.91 6.87e-3 76/85 (89.41%) VWF;PROCR;SERPING1;...
Glutathione metabolism -1.97 0.00e+0 43/57 (75.44%) IDH1;SRM;GSTA1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H