Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMA2UYE)

Drug Name
Ro-24-7429 Drug Info
Cross-matching ID
PubChem CID
135422895
ChEBI ID
CHEMBL93522
CAS Number
CAS 139339-45-0
TTD Drug ID
D0XP3W

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 1.95 0.00e+0 93/133 (69.92%) COX5A;NDUFA4L2;ATP6V0E2;...
Parkinson disease 1.92 0.00e+0 176/249 (70.68%) PRKACB;TUBA1A;GNAS;...
Terpenoid backbone biosynthesis 1.84 8.66e-3 18/22 (81.82%) HMGCS1;IDI1;ACAT2;...
Bile secretion -1.78 4.20e-2 68/90 (75.56%) SLC10A2;SLC10A1;ADCY6;...
Endocrine and other factor-regulated calcium reabsorpti... -1.78 4.90e-2 49/53 (92.45%) ADCY6;DNM1;KL;...
Bacterial invasion of epithelial cells -1.80 4.81e-2 59/77 (76.62%) CLTA;DOCK1;FN1;...
Ferroptosis -1.89 2.67e-2 36/41 (87.8%) TP53;ATG7;MAP1LC3C;...
Focal adhesion -1.91 3.56e-2 180/201 (89.55%) MAPK1;EGFR;CCND3;...
Mineral absorption -2.33 0.00e+0 48/60 (80%) MT1HL1;MT2A;MT1X;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H