Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMA3Y8C)

• Drug Name: Fumagillin Drug Info
• Synonyms: MLS002702991; SMR001566800; NCGC00163699-01; AC1NS4EN; SCHEMBL6953272; MEGxm0_000010; CHEMBL1396346; BDBM95462; ACon0_000963; MolPort-044-567-755; cid_45281154; MolPort-001-739-223; MCULE-6695017352; NCGC00163699-03; J-014992; Fumagillin from Aspergillus fumigatus, > =90%, powder; NCGC00163699-03_C26H34O7_2,4,6,8-Decatetraenedioic acid, mono[5-methoxy-4-[2-methyl-3-(3-methyl-2-buten-1-yl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] ester, (2E,4E,6E,8E)-
• Cross-matching ID:
  PubChem CID: 6917655
  ChEBI ID: CHEMBL48635
  CAS Number: CAS 23110-15-8
  TTD Drug ID: D08CFL

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Apelin signaling pathway	1.97	1.04e-2	117/137 (85.4%)	SERPINE1;CCN2;MYLK;...
TGF-beta signaling pathway	1.96	5.20e-3	81/94 (86.17%)	ID3;ID4;SMAD7;...
Melanoma	1.94	3.47e-3	68/72 (94.44%)	E2F2;MITF;MET;...
Hippo signaling pathway	1.84	2.08e-2	120/186 (64.52%)	SERPINE1;CCN2;SMAD7;...
Cellular senescence	1.81	2.91e-2	139/156 (89.1%)	SERPINE1;ZFP36L1;E2F2;...
Mucin type O-glycan biosynthesis	-1.66	4.97e-2	20/36 (55.56%)	GALNT7;B3GNT3;C1GALT1C1;...
N-Glycan biosynthesis	-1.69	4.23e-2	38/50 (76%)	ALG6;DOLK;ALG5;...
Glutathione metabolism	-1.70	4.49e-2	43/57 (75.44%)	GCLM;GSS;GSTT2;...
Arachidonic acid metabolism	-1.70	4.45e-2	48/61 (78.69%)	TBXAS1;GPX3;ALOX15B;...
Ferroptosis	-1.71	4.26e-2	36/41 (87.8%)	GCLM;CP;GSS;...
Lysosome	-1.77	3.20e-2	115/128 (89.84%)	CTSW;HYAL1;LAPTM4B;...
Sulfur metabolism	-1.78	3.65e-2	9/10 (90%)	ETHE1;SQOR;SUOX;...
Glycosaminoglycan degradation	-1.82	2.16e-2	19/19 (100%)	HYAL1;HYAL2;HPSE;...
Metabolism of xenobiotics by cytochrome P450	-1.94	0.00e+0	49/77 (63.64%)	GSTT2;GSTK1;HPGDS;...
Terpenoid backbone biosynthesis	-2.01	0.00e+0	18/22 (81.82%)	HMGCS2;FDPS;ACAT2;...
Steroid biosynthesis	-2.16	0.00e+0	19/20 (95%)	CYP27B1;SC5D;LBR;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	6.66uM	72H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Show ▼