Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMA4MRX)

Drug Name
Perphenazine Drug Info
Synonyms
Chlorperphenazine; Chlorpiprazine; Decentan; Emesinal; Etaperazin; Etaperazine; Ethaperazine; Fentazin;PZC; Perfenazina; Perfenazine; Perphenan; Perphenazin; Perphenazinum; Thilatazin; Tranquisan; Trifaron; Trilafon; Trilifan; Triphenot; Perfenazina [Italian]; Perphenazine [Trilafon]; Perphenazine maleate; P 6402; Sch 3940; Apo-Perphenazine; F-mon; Perfenazina [INN-Spanish]; Perphenazinum [INN-Latin]; SCH-3940; Siquil (TN); Triavil (TN); Perphenazine [INN:BAN:JAN]; Perphenazine (JP15/USP/INN); Gamma-[4-(beta-Hydroxyethyl)piperazin-1-yl]propyl-2-chlorophenothiazine; Gamma-(4-(beta-Hydroxyethyl)piperazin-1-yl)propyl-2-chlorophenothiazine; 1',1-(2-Idrossietil)-4,3-(2-cloro-10-fenotiazil)propilpiperazina; 1',1-(2-Idrossietil)-4,3-(2-cloro-10-fenotiazil)propilpiperazina [Italian]; 1-(2-Hydroxyethyl)-4-(3-(2-chloro-10-phenothiazinyl)propyl)piperazine; 1-(2-Hydroxyethyl)-4-[3-(2-chloro-10-phenothiazinyl)propyl]piperazine; 1-Piperazineethanol, 4-[3-(2-chlorophenothiazin-10-yl)propyl]-, trihydrochloride; 2-(4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl)ethanol; 2-Chloro-10-(3-(1-(2-hydroxyethyl)-4-piperazinyl)propyl)phenothiazine; 2-Chloro-10-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)phenothiazine; 2-Chloro-10-3-(1-(2-hydroxyethyl)-4-piperazinyl)propyl phenothiazine; 2-Chloro-10-3-[1-(2-hydroxyethyl)-4-piperazinyl]propyl phenothiazine; 2-Chloro-10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazine; 2-[4-[3-(2-Chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethanol;2-{4-[3-(2-Chloro-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethanol; 2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethanol; 4-(3-(2-Chlorophenothiazin-10-yl)propyl)-1-piperazineethanol; 4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol; 4-[3-(2-Chlorophenothiazin-10-yl)propyl]-1-piperazineethanol
Therapeutic ClassAntipsychotic Agents
Cross-matching ID
PubChem CID
4748
ChEBI ID
CHEMBL567
CAS Number
CAS 58-39-9
TTD Drug ID
D02HED
VARIDT Drug ID
DR00759
INTEDE Drug ID
DR1264
ACDINA Drug ID
D00521

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.27 0.00e+0 19/20 (95%) MSMO1;SQLE;DHCR24;...
Lysosome 2.20 0.00e+0 115/128 (89.84%) NPC1;NPC2;TPP1;...
PPAR signaling pathway 2.20 0.00e+0 66/74 (89.19%) HMGCS1;SCD;FADS2;...
Terpenoid backbone biosynthesis 2.09 0.00e+0 18/22 (81.82%) HMGCS1;IDI1;FDPS;...
mTOR signaling pathway 2.02 3.34e-3 114/154 (74.03%) RRAGD;LPIN1;RRAGC;...
Phagosome 1.92 9.73e-3 118/152 (77.63%) NCF2;ATP6V1B2;TLR2;...
Biosynthesis of unsaturated fatty acids 1.92 8.34e-3 21/27 (77.78%) SCD;FADS1;FADS2;...
Amino sugar and nucleotide sugar metabolism 1.82 3.02e-2 38/48 (79.17%) GNPDA1;AMDHD2;HEXB;...
Synthesis and degradation of ketone bodies 1.82 2.69e-2 9/10 (90%) HMGCS1;ACAT2;OXCT1
Synaptic vesicle cycle 1.82 2.42e-2 63/78 (80.77%) STX3;SLC1A3;ATP6V1B2;...
AMPK signaling pathway 1.76 4.17e-2 106/120 (88.33%) SCD;HMGCR;FOXO3;...
Protein processing in endoplasmic reticulum -1.78 2.34e-2 127/171 (74.27%) EDEM1;DERL2;EIF2S1;...
IL-17 signaling pathway -1.78 2.73e-2 84/94 (89.36%) IKBKE;CXCL6;CHUK;...
Fanconi anemia pathway -1.80 2.77e-2 36/54 (66.67%) RMI1;FANCI;FAN1;...
Cocaine addiction -1.82 3.47e-2 42/49 (85.71%) FOSB;PRKACA;GRIA2;...
Mismatch repair -1.84 3.78e-2 22/23 (95.65%) SSBP1;PCNA;RPA1;...
DNA replication -2.21 0.00e+0 34/36 (94.44%) POLA1;DNA2;POLD1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 4uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H