Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMA4XGL)

• Drug Name: 1-phenylbiguanide Drug Info
• Synonyms: phenylbiguanide; 1-Phenylbiguanide; Phenyl biguanide; 102-02-3; Phenyldiguanide; Phenylguanide; phenyl diguanide; N-Phenyl-N'-guanylguanidine; N-phenylimidodicarbonimidic diamide; Biguanide, phenyl-; Imidodicarbonimidic diamide, N-phenyl-; UNII-W8PKA3T2I3; BIGUANIDE, 1-PHENYL-; C8H11N5; N-Phenyl-imidocarbonimidic diamide; EINECS 202-998-5; W8PKA3T2I3; CHEMBL13791; CHEBI:75377; P 1426; Imidodicarbonimidicdiamide, N-phenyl-; 1-(diaminomethylidene)-2-phenylguanidine; SR-01000075565; N-phenylbiguanide; N'-phenylbiguanide
• Cross-matching ID:
  PubChem CID: 4780
  ChEBI ID: CHEMBL13791
  CAS Number: CAS 102-02-3
  TTD Drug ID: D0H4NK

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Arginine biosynthesis	2.03	0.00e+0	17/22 (77.27%)	GLUD1;ARG1;GLUD2;...
Proximal tubule bicarbonate reclamation	1.85	3.97e-2	21/23 (91.3%)	GLUD1;FXYD2;GLUD2;...
N-Glycan biosynthesis	1.81	3.30e-2	38/50 (76%)	MAN1C1;MAN2A1;ALG8;...
Cholesterol metabolism	1.81	2.48e-2	44/50 (88%)	LRP2;ABCA1;APOC3;...
Oxidative phosphorylation	-1.93	6.72e-3	93/133 (69.92%)	NDUFB3;PPA1;ATP5ME;...
Rheumatoid arthritis	-2.09	5.04e-3	78/93 (83.87%)	ATP6V1C1;IL18;HLA-DQA1;...
Mineral absorption	-2.58	0.00e+0	48/60 (80%)	ATP1A1;STEAP1;SLC31A1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼