Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMA6S1D)

Drug Name
Ropinirole Drug Info
Synonyms
Ropinirol; Ropinirolum; Ropitor; ReQuip CR; ReQuip XL; SKF 101468; Adartrel (TN); Requip (TN); Ropark (TN); Ropinirol[INN-Spanish]; Ropinirole (INN); Ropinirole [INN:BAN]; Ropinirolum [INN-Latin]; Ropitor (TN); SK&F 101468; SK&F-101,468; 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one; 4-[2-(Dipropylamino)ethyl]indoline-2-one; 4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one; 4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one
Therapeutic ClassAntiparkinson Agents
Cross-matching ID
PubChem CID
5095
ChEBI ID
CHEMBL589
CAS Number
CAS 91374-21-9
TTD Drug ID
D0R9EQ
INTEDE Drug ID
DR1440
ACDINA Drug ID
D00606

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
TNF signaling pathway -1.68 4.89e-2 103/112 (91.96%) NFKBIA;MAPK14;TAB2;...
Rheumatoid arthritis -1.74 2.69e-2 78/93 (83.87%) JUN;HLA-DRB1;IL18;...
Pathogenic Escherichia coli infection -1.78 1.82e-2 152/197 (77.16%) CLDN8;ABI1;NFKBIA;...
Salmonella infection -1.80 1.46e-2 198/249 (79.52%) ABI1;NFKBIA;MAPK14;...
Circadian rhythm -1.81 1.67e-2 26/31 (83.87%) BTRC;BHLHE40;RORC;...
Osteoclast differentiation -1.83 1.36e-2 117/127 (92.13%) LILRA4;IFNB1;LILRB4;...
Legionellosis -1.83 1.64e-2 51/57 (89.47%) IL12A;NFKBIA;ARF1;...
Synaptic vesicle cycle -1.88 2.92e-3 63/78 (80.77%) SLC1A1;ATP6V1D;AP2A2;...
IL-17 signaling pathway -1.98 3.90e-3 84/94 (89.36%) FOSB;NFKBIA;MAPK14;...
Mitophagy -2.10 0.00e+0 56/68 (82.35%) TBC1D17;USP8;ATG5;...
Epithelial cell signaling in Helicobacter pylori infect... -2.11 0.00e+0 62/70 (88.57%) CSK;ATP6V1D;ATP6V0E1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H