Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMAC5F2)

Drug Name
SNS-314 Drug Info
Synonyms SN-314
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
24995524
ChEBI ID
CHEMBL482767
CAS Number
CAS 1057249-41-8
TTD Drug ID
D0OA5G

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mineral absorption 2.07 0.00e+0 48/60 (80%) MT1G;MT1X;MT1E;...
Melanoma 1.89 2.87e-2 68/72 (94.44%) PDGFC;PDGFRA;MET;...
Folate biosynthesis -1.74 4.83e-2 23/26 (88.46%) PAH;MOCOS;PTS;...
Vasopressin-regulated water reabsorption -1.77 4.56e-2 40/44 (90.91%) DYNLL1;ADCY6;CREB3;...
Terpenoid backbone biosynthesis -1.85 2.59e-2 18/22 (81.82%) FDPS;HMGCS2;MVD;...
Protein processing in endoplasmic reticulum -1.89 1.73e-2 127/171 (74.27%) ERP29;MAPK10;FBXO2;...
PPAR signaling pathway -1.91 1.55e-2 66/74 (89.19%) SORBS1;PLIN1;ACADM;...
Steroid biosynthesis -2.14 0.00e+0 19/20 (95%) HSD17B7;FDFT1;LSS;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H