Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMACBIW)

• Drug Name: WIN-55212-2 Drug Info
• Synonyms: Win-55212-2; WIN 55212-2; UNII-5H31GI9502; 131543-22-1; CHEMBL188; WIN55212-2; WIN 55,212-2; CHEBI:73295; 5H31GI9502; (2,3-Dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl)methanone monomethanesulfonate; [(3R)-5-methyl-3-(morpholin-4-ylmethyl)-2,3-dihydro[1,4]oxazino[2,3,4-hi]indol-6-yl](1-naphthyl)methanone; (r)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone
• Cross-matching ID:
  PubChem CID: 5311501
  ChEBI ID: CHEMBL188
  CAS Number: CAS 131543-22-1
  TTD Drug ID: D0J7RW
  INTEDE Drug ID: DR1718

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Starch and sucrose metabolism	2.08	0.00e+0	25/36 (69.44%)	HK2;GYS1;PYGB;...
Mucin type O-glycan biosynthesis	1.96	0.00e+0	20/36 (55.56%)	GALNT3;GALNT1;GALNT12;...
Thiamine metabolism	1.85	3.08e-2	12/15 (80%)	AK5;ALPG;AK4;...
p53 signaling pathway	-1.84	4.23e-2	63/73 (86.3%)	CCNG1;CDKN2A;EI24;...
Rheumatoid arthritis	-2.04	4.88e-3	78/93 (83.87%)	HLA-DRB1;ATP6V0B;FOS;...
Legionellosis	-2.23	0.00e+0	51/57 (89.47%)	NFKB1;IL12B;RAB1B;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow

Neuroblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
SH-SY5Y	CVCL_0019	Homo sapiens	0.04uM - 10uM	24H	Hide ▲
SK-N-SH	CVCL_0531	Homo sapiens	0.04uM - 10uM	24H	Hide ▲