Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMAD2OZ)

Drug Name
Palovarotene Drug Info
Synonyms R-667; RG-667; Retinoid receptor agonist, Roche; Ro-3300074; Ro-330074
Cross-matching ID
PubChem CID
10295295
CAS Number
CAS 410528-02-8
TTD Drug ID
D0H8OH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Type I diabetes mellitus 2.01 3.44e-2 38/43 (88.37%) HLA-DRB1;HLA-DRA;ICA1;...
Osteoclast differentiation 2.01 1.72e-2 117/127 (92.13%) PPARG;CTSK;AKT3;...
Graft-versus-host disease 1.89 1.15e-2 32/42 (76.19%) HLA-DRB1;HLA-DRA;HLA-A;...
Allograft rejection 1.87 2.01e-2 32/38 (84.21%) HLA-DRB1;HLA-DRA;HLA-A;...
Neutrophil extracellular trap formation 1.86 2.06e-2 101/189 (53.44%) SRC;MPO;CYBB;...
Non-alcoholic fatty liver disease 1.85 1.72e-2 126/155 (81.29%) CXCL8;CDC42;PPARG;...
TNF signaling pathway 1.83 1.47e-2 103/112 (91.96%) CXCL5;TNFAIP3;AKT3;...
Oxidative phosphorylation 1.82 1.58e-2 93/133 (69.92%) ATP5MC2;COX7B;ATP5PD;...
African trypanosomiasis 1.80 2.29e-2 32/37 (86.49%) HBB;SELE;LAMA4;...
Phagosome 1.80 2.06e-2 118/152 (77.63%) HLA-DRB1;MPO;HLA-DRA;...
Rheumatoid arthritis 1.80 1.88e-2 78/93 (83.87%) CXCL8;CXCL5;HLA-DRB1;...
Inflammatory bowel disease 1.78 1.91e-2 58/65 (89.23%) HLA-DRB1;STAT4;HLA-DRA;...
Natural killer cell mediated cytotoxicity 1.77 1.94e-2 99/131 (75.57%) PIK3R1;FCER1G;FCGR3B;...
T cell receptor signaling pathway 1.71 2.87e-2 93/104 (89.42%) CDC42;AKT3;PIK3R1;...
Galactose metabolism 1.70 2.98e-2 26/31 (83.87%) AKR1B10;PFKL;HK2;...
Nucleotide excision repair 1.69 3.15e-2 40/47 (85.11%) PCNA;RFC5;RAD23B;...
Staphylococcus aureus infection 1.69 3.04e-2 72/95 (75.79%) KRT13;KRT19;HLA-DRB1;...
Leishmaniasis 1.69 2.93e-2 67/77 (87.01%) HLA-DRB1;HLA-DRA;CYBB;...
Th17 cell differentiation 1.69 2.84e-2 95/107 (88.79%) HLA-DRB1;HLA-DRA;SMAD3;...
Malaria 1.67 2.92e-2 44/50 (88%) HBB;CXCL8;KLRB1;...
Arachidonic acid metabolism 1.67 3.11e-2 48/61 (78.69%) GPX2;PTGIS;ALOX5;...
Yersinia infection 1.66 3.23e-2 120/137 (87.59%) CXCL8;CDC42;SRC;...
Asthma 1.66 3.19e-2 25/31 (80.65%) HLA-DRB1;HLA-DRA;FCER1G;...
Shigellosis 1.64 3.78e-2 180/246 (73.17%) CXCL8;CDC42;SRC;...
Coronavirus disease 1.63 4.22e-2 215/232 (92.67%) CXCL8;CFD;CYBB;...
Herpes simplex virus 1 infection 1.63 4.10e-2 165/498 (33.13%) HLA-DRB1;SRC;CD74;...
Protein digestion and absorption -1.95 1.61e-2 78/103 (75.73%) COL6A2;COL17A1;COL4A3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H