Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMAEDQG)

• Drug Name: EMODIN Drug Info
• Synonyms: emodin; 518-82-1; Emodol; Schuttgelb; Frangula emodin; Rheum emodin; Frangulic acid; 3-Methyl-1,6,8-trihydroxyanthraquinone; Archin; 1,3,8-trihydroxy-6-methylanthracene-9,10-dione; Persian Berry Lake; 1,3,8-Trihydroxy-6-methyl-9,10-anthraquinone; 6-Methyl-1,3,8-trihydroxyanthraquinone; C.I. Natural Yellow 14; 9,10-Anthracenedione, 1,3,8-trihydroxy-6-methyl-; 1,3,8-Trihydroxy-6-methylanthraquinone; 1,3,8-Trihydroxy-6-methyl-9,10-anthracenedione; 4,5,7-Trihydroxy-2-methylanthraquinone; UNII-KA46RNI6HN; C.I. 75440; NSC 622947
• Cross-matching ID:
  PubChem CID: 3220
  ChEBI ID: CHEMBL289277
  CAS Number: CAS 518-82-1
  TTD Drug ID: D0U7OU

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.21	0.00e+0	34/36 (94.44%)	PRIM1;POLA1;POLE2;...
Mismatch repair	2.03	0.00e+0	22/23 (95.65%)	RFC4;EXO1;RPA3;...
Fanconi anemia pathway	1.93	9.98e-3	36/54 (66.67%)	BRCA1;RMI1;FANCI;...
Renin-angiotensin system	1.91	1.25e-2	20/23 (86.96%)	MME;ENPEP;ANPEP
Melanogenesis	1.90	1.20e-2	74/101 (73.27%)	PLCB1;LEF1;TCF7;...
Nucleotide excision repair	1.86	1.33e-2	40/47 (85.11%)	MNAT1;POLE2;RFC4;...
One carbon pool by folate	1.85	1.14e-2	15/20 (75%)	MTHFD1;MTHFD2;SHMT2;...
Glycine, serine and threonine metabolism	1.77	3.49e-2	31/40 (77.5%)	PSAT1;PHGDH;CBS;...
Homologous recombination	1.76	3.11e-2	35/41 (85.37%)	BRCA1;RAD54B;RBBP8;...
Vascular smooth muscle contraction	1.73	4.29e-2	113/133 (84.96%)	ACTA2;PLCB1;PRKCQ;...
Systemic lupus erythematosus	-1.71	4.51e-2	45/135 (33.33%)	C8A;ACTN4;SNRPD3;...
Viral protein interaction with cytokine and cytokine re...	-1.75	3.72e-2	84/100 (84%)	CCL13;CXCL5;CCR2;...
Toll-like receptor signaling pathway	-1.80	3.17e-2	94/104 (90.38%)	LBP;IRF5;MAP2K3;...
Staphylococcus aureus infection	-1.84	2.00e-2	72/95 (75.79%)	C5;C1S;ITGAM;...
Pertussis	-1.97	2.51e-3	64/76 (84.21%)	FOS;C2;TNF;...
Cholesterol metabolism	-1.98	3.34e-3	44/50 (88%)	ANGPTL8;STAR;LIPA;...
Steroid biosynthesis	-2.17	0.00e+0	19/20 (95%)	SOAT1;TM7SF2;FDFT1;...
Complement and coagulation cascades	-2.23	0.00e+0	76/85 (89.41%)	C1R;C8G;CFHR2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H	Hide ▲

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	0.08uM - 20uM	3H, 24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.08uM - 20uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Show ▼