Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMAET6F)

Drug Name
SB 203580 Drug Info
Synonyms
152121-47-6; SB-203580; SB203580; 4-(4-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine; 4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-5-(4-pyridyl)-1H-imidazole; CHEBI:90705; 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole; CHEMBL10; RWJ 64809; 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole; 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine; PB 203580; UNII-WS78QR6DSV
Cross-matching ID
PubChem CID
176155
ChEBI ID
CHEMBL10
CAS Number
CAS 152121-47-6
TTD Drug ID
D0F8DL

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.48 0.00e+0 34/36 (94.44%) RFC2;PCNA;POLE2;...
Mismatch repair 2.13 0.00e+0 22/23 (95.65%) RFC2;PCNA;MSH2;...
Nucleotide excision repair 2.03 2.94e-3 40/47 (85.11%) RFC2;PCNA;POLE2;...
Progesterone-mediated oocyte maturation 1.88 8.83e-3 75/100 (75%) CDK1;CCNB2;PRKACB;...
Homologous recombination 1.88 7.07e-3 35/41 (85.37%) BRCA1;RAD54B;RPA3;...
Cell cycle 1.84 1.03e-2 110/124 (88.71%) CDC20;PCNA;CDK1;...
Base excision repair 1.83 8.83e-3 29/33 (87.88%) PCNA;POLE2;PARP2;...
Aminoacyl-tRNA biosynthesis 1.80 1.10e-2 15/66 (22.73%) DARS2;GATB;GATC;...
Pyrimidine metabolism 1.73 2.55e-2 40/56 (71.43%) NT5E;RRM1;DPYD;...
ABC transporters -1.69 3.19e-2 37/45 (82.22%) ABCB9;ABCC1;ABCB7;...
Ether lipid metabolism -1.70 3.26e-2 32/49 (65.31%) PLA2G7;PLPP1;PLA2G1B;...
Allograft rejection -1.73 2.92e-2 32/38 (84.21%) FASLG;IL10;HLA-DPA1;...
Pancreatic secretion -1.73 3.06e-2 87/102 (85.29%) ADCY9;PLA2G2D;CELA3B;...
Proximal tubule bicarbonate reclamation -1.75 2.93e-2 21/23 (91.3%) ATP1A3;MDH1;GLS2;...
Intestinal immune network for IgA production -1.78 1.65e-2 38/48 (79.17%) HLA-DOB;CXCR4;CCL25;...
Viral protein interaction with cytokine and cytokine re... -1.79 1.70e-2 84/100 (84%) IL24;CCL11;IL2RG;...
Vitamin digestion and absorption -1.80 1.51e-2 17/24 (70.83%) MMACHC;ABCC1;SLC19A2;...
Mitophagy -1.81 1.56e-2 56/68 (82.35%) AMBRA1;RHOT2;BCL2L1;...
Staphylococcus aureus infection -1.83 1.30e-2 72/95 (75.79%) C5;KRT24;DEFA4;...
Primary immunodeficiency -1.87 3.79e-3 33/38 (86.84%) TAP2;IL7R;CD3D;...
Bile secretion -1.93 0.00e+0 68/90 (75.56%) FXYD2;CYP7A1;UGT2B4;...
Fat digestion and absorption -2.00 0.00e+0 35/43 (81.4%) PNLIPRP1;MTTP;PLPP3;...
Ferroptosis -2.06 0.00e+0 36/41 (87.8%) MAP1LC3B;SLC39A8;ACSL1;...
Protein digestion and absorption -2.07 0.00e+0 78/103 (75.73%) COL9A1;ATP1A3;PRSS1;...
Steroid hormone biosynthesis -2.14 0.00e+0 43/61 (70.49%) CYP11B1;CYP3A7;UGT2B15;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 12.5uM 6H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 12.5uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.08uM - 10uM 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.08uM - 10uM 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.08uM - 10uM 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.08uM - 10uM 6H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H