Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMAFPHB)

• Drug Name: TRYPTAMINE Drug Info
• Synonyms: tryptamine; 61-54-1; 2-(1H-Indol-3-yl)ethanamine; 3-(2-aminoethyl)indole; 1H-Indole-3-ethanamine; 2-(3-Indolyl)ethylamine; Indol-3-ethylamine; Indole, 3-(2-aminoethyl)-; 2-(Indol-3-yl)ethylamine; 2-(1H-Indol-3-Yl)Ethan-1-Amine; 3-Indoleethylamine; Tryptamin; 2-(1H-indol-3-yl)ethylamine; 2-Indol-3-ylethylamine; 2-(1H-INDOL-3-YL)-ETHYLAMINE; UNII-422ZU9N5TV; (Amino-2 ethyl)-3 indole; (Amino-2 ethyl)-3 indole [French]; Tryptamine, 98%; BRN 0125513; EINECS 200-510-5; CHEMBL6640; 422ZU9N5TV; CHEBI:16765; APJYDQYYACXCRM-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 1150
  ChEBI ID: CHEMBL6640
  CAS Number: CAS 61-54-1
  TTD Drug ID: D08CJK

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Metabolism of xenobiotics by cytochrome P450	2.05	2.10e-2	49/77 (63.64%)	AKR1C1;CYP1B1;AKR7A2;...
Glutathione metabolism	1.88	3.14e-2	43/57 (75.44%)	ANPEP;G6PD;GSTA1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	12uM - 100uM	48H	Hide ▲

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	12uM - 100uM	48H	Hide ▲