Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMAH70G)

• Drug Name: Molindone Drug Info
• Synonyms: Molindona; Molindonum; Molindone Monohydrochloride; Molindona [INN-Spanish]; Molindone (INN); Molindone (MOL); Molindone [INN:BAN]; Molindonum [INN-Latin]; (+-)-Molindone; 3-Ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-4H-indol-4-one; 3-Ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)indol-4(5H)-one; 3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydro-4H-indol-4-one; 3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one; 3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-4,5,6,7-tetrahydro-1H-indol-4-one
• Therapeutic Class: Antipsychotic Agents
• Cross-matching ID:
  PubChem CID: 23897
  ChEBI ID: CHEMBL460
  CAS Number: CAS 7416-34-4
  TTD Drug ID: D09TPF
  ACDINA Drug ID: D00444

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Spliceosome	1.91	2.75e-2	101/150 (67.33%)	HSPA8;SNRPB;PUF60;...
Cell cycle	1.87	1.72e-2	110/124 (88.71%)	PCNA;SMC1A;CDC20;...
Base excision repair	1.83	1.37e-2	29/33 (87.88%)	PCNA;POLE2;FEN1;...
DNA replication	1.80	2.40e-2	34/36 (94.44%)	PCNA;MCM6;POLE2;...
Fanconi anemia pathway	1.76	2.47e-2	36/54 (66.67%)	FANCL;REV3L;HES1;...
Ribosome biogenesis in eukaryotes	1.74	2.52e-2	52/108 (48.15%)	POP5;IMP3;NOP56;...
Proteasome	1.67	4.91e-2	44/46 (95.65%)	PSMA4;PSMC6;PSMA6;...
Proximal tubule bicarbonate reclamation	-1.73	4.62e-2	21/23 (91.3%)	PCK1;SLC4A4;GLUD2;...
PPAR signaling pathway	-1.74	4.75e-2	66/74 (89.19%)	SLC27A2;FABP5;MMP1;...
Riboflavin metabolism	-1.79	4.16e-2	7/8 (87.5%)	ENPP1;ACP2;ACP1;...
Renin-angiotensin system	-1.82	4.04e-2	20/23 (86.96%)	AGTR1;CTSA;ACE2;...
Ferroptosis	-1.87	1.78e-2	36/41 (87.8%)	ACSL4;VDAC2;NCOA4;...
Nitrogen metabolism	-1.93	3.96e-3	16/17 (94.12%)	CPS1;CA9;GLUD2;...
Complement and coagulation cascades	-1.94	5.94e-3	76/85 (89.41%)	FGB;CFHR5;CPB2;...
Steroid biosynthesis	-2.01	0.00e+0	19/20 (95%)	EBP;LSS;TM7SF2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	6.66uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼