Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMAI95U)

Drug Name
PMID25656651-Compound-5 Drug Info
Cross-matching ID
PubChem CID
24826799
ChEBI ID
CHEMBL1171837
CAS Number
CAS 943319-70-8
TTD Drug ID
D0WL1U
ACDINA Drug ID
D00541

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycine, serine and threonine metabolism 2.36 0.00e+0 31/40 (77.5%) PHGDH;PSAT1;CBS;...
Cysteine and methionine metabolism 2.20 0.00e+0 43/50 (86%) PHGDH;PSAT1;CBS;...
One carbon pool by folate 1.96 2.50e-3 15/20 (75%) SHMT2;MTHFD2;AMT;...
Terpenoid backbone biosynthesis 1.96 1.88e-3 18/22 (81.82%) ACAT2;HMGCS1;HMGCR;...
Alanine, aspartate and glutamate metabolism 1.93 1.50e-3 27/37 (72.97%) ASNS;ASS1;GOT1;...
Glyoxylate and dicarboxylate metabolism 1.89 3.75e-3 23/30 (76.67%) SHMT2;ACAT2;AMT;...
Steroid biosynthesis 1.83 8.58e-3 19/20 (95%) SQLE;CYP51A1;MSMO1;...
Butanoate metabolism 1.74 2.81e-2 23/28 (82.14%) ACAT2;HMGCS1;ALDH5A1;...
Antigen processing and presentation -1.67 2.35e-2 60/78 (76.92%) CTSS;CALR;IFNG;...
Phagosome -1.68 2.10e-2 118/152 (77.63%) SEC61G;CTSS;CALR;...
Prion disease -1.70 1.87e-2 209/273 (76.56%) C9;CCL5;PSMB2;...
Proteoglycans in cancer -1.70 1.94e-2 172/205 (83.9%) PLCG2;ARHGEF1;IGF1;...
Various types of N-glycan biosynthesis -1.71 1.87e-2 26/39 (66.67%) HEXB;B4GALT3;B4GALT2;...
NF-kappa B signaling pathway -1.72 1.61e-2 90/104 (86.54%) LTA;MALT1;TNFRSF1A;...
Pertussis -1.72 1.67e-2 64/76 (84.21%) NFKB1;IL1A;MYD88;...
Focal adhesion -1.73 1.59e-2 180/201 (89.55%) ITGB6;RHOA;GSK3B;...
Small cell lung cancer -1.75 1.38e-2 90/92 (97.83%) ITGAV;COL4A1;E2F2;...
Kaposi sarcoma-associated herpesvirus infection -1.76 1.39e-2 172/193 (89.12%) IKBKG;MAP2K1;BID;...
Glycosaminoglycan biosynthesis -1.76 1.28e-2 40/58 (68.97%) B4GALT3;B4GALT2;EXTL2;...
AGE-RAGE signaling pathway in diabetic complications -1.76 1.35e-2 97/100 (97%) CASP3;PLCG2;TGFB2;...
Lipid and atherosclerosis -1.79 6.76e-3 190/215 (88.37%) CCL5;MAP2K7;TNFRSF1A;...
Bladder cancer -1.82 3.58e-3 40/41 (97.56%) E2F2;DAPK3;FGFR3;...
Inflammatory bowel disease -1.86 3.04e-3 58/65 (89.23%) IL2RG;SMAD2;IL10;...
Cytokine-cytokine receptor interaction -1.86 3.25e-3 246/295 (83.39%) CCR3;FAS;LTA;...
Leishmaniasis -1.86 3.48e-3 67/77 (87.01%) TGFB2;NFKB1;IL1A;...
Galactose metabolism -1.88 3.74e-3 26/31 (83.87%) LCT;SI;B4GALT2;...
Malaria -1.89 0.00e+0 44/50 (88%) IFNG;MYD88;ICAM1;...
Cholesterol metabolism -1.90 0.00e+0 44/50 (88%) STARD3;MYLIP;ABCG5;...
Toxoplasmosis -1.93 0.00e+0 103/112 (91.96%) IFNG;MYD88;HLA-DRA;...
Epithelial cell signaling in Helicobacter pylori infect... -1.95 0.00e+0 62/70 (88.57%) CCL5;CASP3;PLCG2;...
Hematopoietic cell lineage -1.96 0.00e+0 90/99 (90.91%) IL1A;IL4R;IL5RA;...
Amoebiasis -1.97 0.00e+0 99/102 (97.06%) C8G;TGFB2;NFKB1;...
Viral protein interaction with cytokine and cytokine re... -2.00 0.00e+0 84/100 (84%) CXCR5;TNFSF14;TNFRSF10C;...
Proteasome -2.05 0.00e+0 44/46 (95.65%) PSMB2;PSMC3;PSMA7;...
Legionellosis -2.12 0.00e+0 51/57 (89.47%) RAB1B;TLR2;TLR4;...
ECM-receptor interaction -2.21 0.00e+0 80/88 (90.91%) ITGB6;LAMA2;VWF;...
IL-17 signaling pathway -2.21 0.00e+0 84/94 (89.36%) TRAF3IP2;HSP90AB1;MAP3K7;...
Rheumatoid arthritis -2.25 0.00e+0 78/93 (83.87%) ACP5;IFNG;HLA-DRA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 0.12uM - 1.11uM 24H
TC-32 CVCL_7141 Homo sapiens 0.12uM - 1.11uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 0.12uM - 10uM 24H
YH-13 CVCL_1800 Homo sapiens 0.12uM - 1.11uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 0.12uM - 1.11uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.08uM - 10uM 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 0.12uM - 1.11uM 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.08uM - 10uM 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.08uM - 10uM 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.08uM - 10uM 6H, 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.12uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 0.12uM - 1.11uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.12uM - 10uM 24H
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GP2d CVCL_1234 Homo sapiens 0.12uM - 10uM 24H
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
SNU-407 CVCL_5004 Homo sapiens 0.12uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.12uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.12uM - 10uM 24H
HEC-151 CVCL_2927 Homo sapiens 0.12uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.12uM - 1.11uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.12uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.12uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
CJM CVCL_U797 Homo sapiens 0.12uM - 1.11uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 0.12uM - 1.11uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.12uM - 1.11uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 3.33uM 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 0.12uM - 10uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.12uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H, 48H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
NCI-H1437 CVCL_1472 Homo sapiens 0.12uM - 1.11uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 0.12uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 0.12uM - 1.11uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.12uM - 1.11uM 24H
HCC1588 CVCL_1263 Homo sapiens 0.12uM - 1.11uM 24H
HCC95 CVCL_1276 Homo sapiens 0.12uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
NCI-H2110 CVCL_1529 Homo sapiens 0.12uM - 1.11uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.12uM - 1.11uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H841 CVCL_1595 Homo sapiens 0.12uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.12uM - 10uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 0.12uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVK18 CVCL_1629 Homo sapiens 0.12uM - 10uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.12uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.12uM - 1.11uM 24H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 0.12uM - 10uM 24H
OC 316 CVCL_1615 Homo sapiens 0.12uM - 10uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 0.12uM - 1.11uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.12uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.12uM - 1.11uM 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.12uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
IGR-37 CVCL_1303 Homo sapiens 0.12uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.12uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 0.12uM - 1.11uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
SK-MEL-3 CVCL_0525 Homo sapiens 0.12uM - 1.11uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM - 10uM 24H
MKN45 CVCL_0434 Homo sapiens 0.12uM - 10uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.12uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 0.12uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.12uM - 1.11uM 24H